ISAS Kompakt

Ready, set, slam!

Six science slams, a packed lecture hall and fascinating insights into cardiovascular research: at the HI-FIVE Science Slam on World Heart Day, a clinican and five early-career researchers brought science to the stage. Through humour and engaging storytelling, they brought complex scientific topics to life and gave the audience an insight into HI-FIVE’s research into new approaches to treating heart failure.

In Memory of Günther Tölg

Prof. Dr Günther Tölg has passed away at the age of 97. As director, he led ISAS for over 13 years and played a key role in shaping the institute’s development. ISAS remembers his longstanding contribution with great appreciation.

• #Cancer
• #Cancer therapy
• #Interview
• #Mass Spectrometry Imaging (MSI)

Endogenous Antioxidant Promotes Breast Cancer Cells in the Lung

Oxidative stress puts pressure on metastasising tumour cells – yet they can activate defence mechanisms to cope with it. Prof. Dr Dr Alpaslan Tasdogan explains the specific challenges faced by breast cancer cells in the lungs. In the interview, he discusses the therapeutic potential of specifically targeting these defence mechanisms of tumour cells in the future.

• #AI

An AI Agent That Understands the Language of Science

A colleague who never sleeps, never gets tired and completes complex analyses in minutes: a new AI agent for biomedical research is to be developed at ISAS.

• #Cancer
• #Cancer therapy
• #Mass Spectrometry Imaging (MSI)
• #Metabolomics
• #Metastases

Endogenous Antioxidant Promotes Breast Cancer Cells in Lungs

How do breast cancer cells manage to establish themselves in the lungs and survive there? Researchers at ISAS are investigating which metabolic processes help the tumour cells to adapt to their new environment. The findings provide new insights into the early stages of metastases.

From Human Stem Cells to Mice: Research into New Treatments for Heart Failure

What can human stem cells tell us, and why are mice still essential for developing new therapies for people with heart failure? In our collaborative project HI-FIVE, scientists and physicians work with both animal-free methods and, for some research questions, with mice. In this article marking World Day for Laboratory Animals, our animal welfare officer and the lead researcher of HI-FIVE explain why.