ISAS Kompakt

• #Cancer
• #Cancer therapy
• #Interview
• #Mass Spectrometry Imaging (MSI)

Endogenous Antioxidant Promotes Breast Cancer Cells in the Lung

Oxidative stress puts pressure on metastasising tumour cells – yet they can activate defence mechanisms to cope with it. Prof. Dr Dr Alpaslan Tasdogan explains the specific challenges faced by breast cancer cells in the lungs. In the interview, he discusses the therapeutic potential of specifically targeting these defence mechanisms of tumour cells in the future.

• #AI

An AI Agent That Understands the Language of Science

A colleague who never sleeps, never gets tired and completes complex analyses in minutes: a new AI agent for biomedical research is to be developed at ISAS.

• #Cancer
• #Cancer therapy
• #Mass Spectrometry Imaging (MSI)
• #Metabolomics
• #Metastases

Endogenous Antioxidant Promotes Breast Cancer Cells in Lungs

How do breast cancer cells manage to establish themselves in the lungs and survive there? Researchers at ISAS are investigating which metabolic processes help the tumour cells to adapt to their new environment. The findings provide new insights into the early stages of metastases.

From Human Stem Cells to Mice: Research into New Treatments for Heart Failure

What can human stem cells tell us, and why are mice still essential for developing new therapies for people with heart failure? In our collaborative project HI-FIVE, scientists and physicians work with both animal-free methods and, for some research questions, with mice. In this article marking World Day for Laboratory Animals, our animal welfare officer and the lead researcher of HI-FIVE explain why.

• #Image analysis
• #Immune cells
• #Interview
• #Lipidomics
• #Neutrophils
• #Proteomics

Four Perspectives on a Shared Discovery

Although CD177⁺ and CD177⁻ neutrophils look identical under the microscope, they are in fact not the same. Four of the authors of “CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumour-Promoting Activity” (Advanced Science) explain how they identified the functional differences between these immune cells and which combined analytical methods made their discovery possible in the first place. This insight into their research demonstrates how interdisciplinary collaboration can reveal previously undiscovered information.

• #Heart damage
• #Interview
• #Mass spectrometry
• #Proteomics

3 Questions for... Neele Rottmann

In the lab, Neele Rottmann prepares human and animal samples for mass spectrometry analysis. As part of the HI-FIVE project, she is helping to identify changes at the protein level in heart failure. Why does she spend so much time in the lab working on separations? The technical assistant shares the answer in this interview.