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Advancing Analytics

We develop and combine technologies into four-dimensional analytical methods for health research. Our goal: With our analytics for precision medicine, we want to contribute to optimising the prevention, diagnosis and therapy of various diseases.

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Research Programmes

In our four programmes, we conduct research on various interdisciplinary projects. In one of our research programmes, for example, we combine analytical procedures and develop multi-method concepts in order to elucidate disease mechanisms and identify potential therapeutic approaches - always with a clear application purpose for the following preclinical research.

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ISAS Kompakt

30th April 2025

Humboldt Fellow Prof Dr Xiaowei Xu started at ISAS in March

Prof Dr Xiaowei Xu from the Chinese Guangdong Cardiovascular Institute is researching the clinical application of artificial intelligence (AI) in the context of cardiovascular diseases. For 18 months in total, he will be researching various AI methods for analysing cell images as a Humboldt Fellow at ISAS.

Prof Dr Xiaowei Xu in front of the ISAS city building.
22nd April 2025

Valuable Connections: Dr Mohammad Ibrahim AlWahsh

Dr Mohammad Ibrahim AlWahsh worked as a research assistant at ISAS during his doctorate. He is now Vice Dean of the Faculty of Pharmacy and Assistant Professor of Toxicological Pathology at Al-Zaytoonah University in Jordan. In the Kompakt series ‘Valuable Connections,’ he reports on his time at ISAS and his ongoing network with the institute.

Mohammad Alwahsh.
9th April 2025

Bacteria & Sweets: Schoolgirls Examine their Breath at the Girls’ Day

On Girls' Day 2025, twelve schoolgirls got to know the work of researchers and technical assistants at the institute. They investigated the cause of and fight against inflammation, went on the hunt for bacteria and used ion mobility spectrometry to analyze the aromatic substances of various sweets in their breath.

Luisa Speicher erklärt drei Mädchen den Vortexmischer.
27th March 2025

Valuable Connections: Dr Jianxu Chen

Dr Jianxu Chen leads the junior research group AMBIOM - Analysis of Microscopic BIOMedical Images at ISAS since 2021. He previously worked at the Allen Institute for Cell Science in Seattle, USA. In the ISAS -Kompakt series ‘Valuable Connections’, the computer scientist reports on his move to health research and to Germany.

Portrait von Dr.  Jianxu Chen.
12th March 2025

Two-step Analysis is a Thing of the Past Thanks to Innovative Mass Spectrometry

Fast and accurate mass spectrometric detection of non-polar substances such as cholesterol together with polar substances? And in just one analysis run? This is made possible by a new combination method that unites two ionization sources in one setup.

Daniel Foest steht im Labor und hält ein Papier mit einer Leberprobe, die er am Massenspektrometer untersucht.
26th February 2025

What are you doing at ISAS, Leon?

What do marshmallows and chocolate have to do with cell analysis? Leon is finding out the answer during his school internship at ISAS. For ISAS Kompakt, the 15-year-old talks about what else he is learning during his time at the institute.

Leon hält Marshmallows, Schokolade und die Hardware für sein Projekt zur Bilderkennung.
14th February 2025

Valentines’ Day: Perfect Couples in the Lab

On Valentine's Day, the editors of ISAS Kompakt wanted to know what makes our researchers' hearts beat faster. The examples from the laboratories of the Bioimaging and NMR Metabolomics research groups show that special bonds do not only exist in love, but also in science.

Porträt von Dr. Themistoklis Venianakis.
4th February 2025

Valuable Connections: Adrian Sebuliba

Adrian Sebuliba joined the ISAS junior research group AMBIOM in 2023 as a software engineer. Previously, he worked for a digital commerce platform for the chemical industry in Uganda. In the ISAS Kompakt series ‘Valuable Connections’, he reports on his move into health research, among other things.

Portrait of Adrian Sebuliba.
28th January 2025

A Small But Very Important Step

Susmita Ghosh joined the Biofluorescence research group at ISAS in October 2021. The PhD student has now received the first funding of her career for her pilot project “Dissecting the neutrophil-tumor cell interactome using SILAC-labelling”.

Portrait Susmita Ghosh.
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Publications

Scientific Data, Vol. 2025, No. 12, 2025

Siemes D, Voss H, Benvenuti F, Simoncello F, Kopczynski D, Siebels B, Schlüter H, Kollipara L, Sickmann A, Engel DR, Shevchuk O.

A reference database enabling in-depth proteome and PTM analysis of mouse immune cells

https://doi.org/10.1038/s41597-025-04829-9

Nature Metabolism, Vol. 7, No. 3, 2025, P. 531-555

Zuhra K, Petrosino M, Janickova L, Petric J, Ascenção K, Vignane T, Khalaf M, Philipp TM, Ravani S, Anand A, Martins V, Santos S, Erdemir S, Malkondu…

Regulation of mammalian cellular metabolism by endogenous cyanide production

https://doi.org/10.1038/s42255-025-01225-w

Applied Surface Science, Vol. 682, 2025

Al-Bataineh Q, Rjoub G, Telfah AD, Ahmad AA, Tavares CJ, Hergenröder R.

Developing surface plasmon resonance imaging for discrete particle detection based on a silver layer coated with polyacrylic acid/iodine polyelectrolyte brushes

https://doi.org/10.1016/j.apsusc.2024.161755

Journal of leukocyte biology, Vol. 117, No. 2, 2025

Cibir Z, Beer A, Kraus A, Pillibeit A, Bludau D, Abdulla H, Neuendorff NR, Sonneck J, Kowitz L, Riese S, Tuz A, Chen J, Cherneha M, Beelen DW,…

Risk beyond neutropenia: insights into neutrophil migration from newly diagnosed AML until late after allogeneic stem cell transplantation

https://doi.org/10.1093/jleuko/qiae250

Acta Neuropathologica Communications, Vol. 13, No. 1, 2025

Della Marina A, Koutsoulidou A, Natera-de Benito D, Tykocinski L, Tomazou M, Georgiou K, Laner A, Kölbel H, Nascimento A, Ortez C, Abicht A, Thakur…

Blood biomarker fingerprints in a cohort of patients with CHRNE-related congenital myasthenic syndrome

https://doi.org/10.1186/s40478-025-01946-9

Journal of Neuroinflammation, Vol. 22, No. 1, 2025

Christ R, Siemes D, Zhao S, Widera L, Spangenberg P, Lill J, Thiebes S, Bottek J, Borgards L, Pinho AG, Silva NA, Monteiro S, Jorch SK, Gunzer M,…

Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology

https://doi.org/10.1186/s12974-025-03356-z

Cell Metabolism, Vol. 2025, No. 37(2), 2025, P. 542-556.e14

Petrovic D, Slade L, Paikopoulos Y, D'Andrea D, Savic N, Stancic A, Miljkovic JL, Vignane T, Drekolia MK, Mladenovic D, Sutulovic N, Refeyton A,…

Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation

https://doi.org/10.1016/j.cmet.2024.12.008

Biomedizinische Technik / Biomedical engineering, Vol. 70, No. 1, 2024, P. 71-90

Li J, Zhou Z, Yang J, Pepe A, Gsaxner C, Luijten G, Qu C, Zhang T, Chen X, Li W, Wodzinski M, Friedrich P, Xie K, Jin Y, Ambigapathy N, Nasca E,…

MedShapeNet - a large-scale dataset of 3D medical shapes for computer vision.

https://doi.org/10.1515/bmt-2024-0396

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