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Advancing Analytics

We develop and combine technologies into four-dimensional analytical methods for health research. Our goal: With our analytics for precision medicine, we want to contribute to optimising the prevention, diagnosis and therapy of various diseases.

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Research Programmes

In our four programmes, we conduct research on various interdisciplinary projects. In one of our research programmes, for example, we combine analytical procedures and develop multi-method concepts in order to elucidate disease mechanisms and identify potential therapeutic approaches - always with a clear application purpose for the following preclinical research.

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ISAS Kompakt

14th May 2025

“Moving to ISAS changed my whole view on mass spectrometry”

Prof Dr Miloš Filipović is researching the connection between ageing processes and gasotransmitter signalling pathways, in particular hydrogen sulphide. The biochemist headed the ERC Sulfaging group at ISAS from October 2020 until February 2025, at which point he was appointed to the University of Glasgow in Scotland. In this interview, he looks back on the past four and a half years in Dortmund and talks about his experiences at ISAS.

Dr. habil. Milos Filipovic.
30th April 2025

Humboldt Fellow Prof Dr Xiaowei Xu started at ISAS in March

Prof Dr Xiaowei Xu from the Chinese Guangdong Cardiovascular Institute is researching the clinical application of artificial intelligence (AI) in the context of cardiovascular diseases. For 18 months in total, he will be researching various AI methods for analysing cell images as a Humboldt Fellow at ISAS.

Prof Dr Xiaowei Xu in front of the ISAS city building.
22nd April 2025

Valuable Connections: Dr Mohammad Ibrahim AlWahsh

Dr Mohammad Ibrahim AlWahsh worked as a research assistant at ISAS during his doctorate. He is now Vice Dean of the Faculty of Pharmacy and Assistant Professor of Toxicological Pathology at Al-Zaytoonah University in Jordan. In the Kompakt series ‘Valuable Connections,’ he reports on his time at ISAS and his ongoing network with the institute.

Mohammad Alwahsh.
9th April 2025

Bacteria & Sweets: Schoolgirls Examine their Breath at the Girls’ Day

On Girls' Day 2025, twelve schoolgirls got to know the work of researchers and technical assistants at the institute. They investigated the cause of and fight against inflammation, went on the hunt for bacteria and used ion mobility spectrometry to analyze the aromatic substances of various sweets in their breath.

Luisa Speicher erklärt drei Mädchen den Vortexmischer.
27th March 2025

Valuable Connections: Dr Jianxu Chen

Dr Jianxu Chen leads the junior research group AMBIOM - Analysis of Microscopic BIOMedical Images at ISAS since 2021. He previously worked at the Allen Institute for Cell Science in Seattle, USA. In the ISAS -Kompakt series ‘Valuable Connections’, the computer scientist reports on his move to health research and to Germany.

Portrait von Dr.  Jianxu Chen.
12th March 2025

Two-step Analysis is a Thing of the Past Thanks to Innovative Mass Spectrometry

Fast and accurate mass spectrometric detection of non-polar substances such as cholesterol together with polar substances? And in just one analysis run? This is made possible by a new combination method that unites two ionization sources in one setup.

Daniel Foest steht im Labor und hält ein Papier mit einer Leberprobe, die er am Massenspektrometer untersucht.
26th February 2025

What are you doing at ISAS, Leon?

What do marshmallows and chocolate have to do with cell analysis? Leon is finding out the answer during his school internship at ISAS. For ISAS Kompakt, the 15-year-old talks about what else he is learning during his time at the institute.

Leon hält Marshmallows, Schokolade und die Hardware für sein Projekt zur Bilderkennung.
14th February 2025

Valentines’ Day: Perfect Couples in the Lab

On Valentine's Day, the editors of ISAS Kompakt wanted to know what makes our researchers' hearts beat faster. The examples from the laboratories of the Bioimaging and NMR Metabolomics research groups show that special bonds do not only exist in love, but also in science.

Porträt von Dr. Themistoklis Venianakis.
4th February 2025

Valuable Connections: Adrian Sebuliba

Adrian Sebuliba joined the ISAS junior research group AMBIOM in 2023 as a software engineer. Previously, he worked for a digital commerce platform for the chemical industry in Uganda. In the ISAS Kompakt series ‘Valuable Connections’, he reports on his move into health research, among other things.

Portrait of Adrian Sebuliba.
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Publications

Analytica Chimica Acta, Vol. 343946, No. 2025, 2025

Fechner A, Höving S, Schiller A, Telgheder U, Franzke J.

Instrumental developments in drift tube ion mobility spectrometry: A review on miniaturization, new manufacturing techniques, and pre-separation

https://doi.org/10.1016/j.aca.2025.343946

Journal of Materials Science, 2025

Al-Bataineh QM, Aljarrah I, Ahmad AA, Rjoub G, Telfah AD, Hergenroeder R.

Surface plasmon coupling between different shapes of silver nanostructures and wide-field SPR microscopy

https://doi.org/10.1007/s10853-025-10917-3

Circulation Research, Vol. 136, No. 10, 2025, P. 1110-1112

Altieri D, Lorenz K, Epelman S.

New Minimally Invasive Myocardial Ischemia/Reperfusion Approach

https://doi.org/10.1161/CIRCRESAHA.125.326461

Journal of Proteome Research, 2025

Smith KW, Fecke A, Kasarla SS, Phapale P.

Large-scale metabolite imaging gallery of mouse organ tissues to study spatial metabolism

https://doi.org/10.21203/rs.3.rs-3891634/v1

Nature Communications, Vol. 16, No. 1, 2025

Müller M, Schubert T, Welke C, Maske T, Patschowski T, Donhauser E, Heinen-Weiler J, Hormann F, Heiles S, Schulz TJ, Lengenfelder LA, Landwehrjohann…

Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice

https://doi.org/10.1038/s41467-025-59192-5

Scientific Data, Vol. 2025, No. 12, 2025, P. 596

Siemes D, Voss H, Benvenuti F, Simoncello F, Kopczynski D, Siebels B, Schlüter H, Kollipara L, Sickmann A, Engel DR, Shevchuk O.

A reference database enabling in-depth proteome and PTM analysis of mouse immune cells

https://doi.org/10.1038/s41597-025-04829-9

PeerJ Computer Science, 2025

Bershadskyy D, Krüger J, Çalikli G, Otto S, Zabel S, Greif J, Heyer R.

A Laboratory Experiment on Using Different Financial-Incentivization Schemes in Software-Engineering Experimentation

https://doi.org/10.48550/arXiv.2202.10985

Communications Medicine, Vol. 2025, No. 5, 2025

Mill L, Aust O, Ackermann JA, Burger P, Pascual M, Palumbo-Zerr K, Krönke G, Uderhardt S, Schett G, Clemen CS, Holtzhausen C, Jabari S, Schröder R,…

Deep learning-based image analysis in muscle histopathology using photo-realistic synthetic data

https://doi.org/10.1038/s43856-025-00777-y

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Open Positions

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