Researchers who analyse complex samples using mass spectrometers are often faced with the challenge that the substances they contain are fundamentally different. Some are chemically polar, others are non-polar. Until now, this has required two complex separate analyses. But a researcher at ISAS has developed a method with which even less polar substances can be included in a standard mass spectrometric analysis for polar biological substances.
Darleen Hüser is looking for the immuno-cellular fingerprint of rheumatoid arthritis. In this interview, the doctoral student reveals her razor-sharp research and why she needs different microscopes.
Talking lab equipment, artificial intelligence and expertise from the North Pole - this colourful mix of topics characterised the latest Science Slam at the institute. Four ISAS employees demonstrated with their specialist knowledge and plenty of humour how science communication can be fun for everyone involved.
What challenges in analysing microscopic images can be mastered with artificial intelligence if the latter is incorporated at an early stage? Why should researchers think about the target metrics of image analysis when planning their experiment? Dr Jianxu Chen has now put together his tips, recently published in the journal Nature Methods, as a kind of checklist for researchers.
The nationwide project recently funded by the German Research Foundation is focussing on inflammation-induced bone loss. Researchers from Dortmund, Dresden, Erlangen/Nuremberg and Ulm want to find out exactly how inflammatory diseases - such as rheumatoid arthritis or intestinal diseases - damage bones. Among other things, their research aims to help identify new therapies for skeletal-associated diseases.
What role does the oxygen levelin the blood play in thrombosis? Joy Amrei Brummel is tackling this and other questions in her bachelor's thesis. The 24-year-old student reports on how she applies her university knowledge in the ISAS laboratory.