How can AI support the analysis of biomedical images? This was the question Lukas Fu explored during his school internship at ISAS. The 15-year-old also successfully completed his first programming project.

When different fluorescence signals overlap during microscopy, their clear assignment to specific biological structures becomes difficult. To address this common problem, Dr Davide Panzeri is developing AI-based signal separation methods. The biophysicist has been awarded a Marie Skłodowska-Curie Fellowship by the European Union for his promising research project.

How do GRK5 inhibitors work at the cellular level and within the living organism? Biologist Dr Susanne Grund is working with her colleagues at HI-FIVE on a new therapeutic approach for heart failure. In this portrait, she describes what her day-to-day work looks like, balancing research on human stem cells with studies on mice.

Why do mice undergo ultrasound examinations of their hearts? What does a typical working day in the lab involve for a technical assistant in the HI-FIVE research project ? And what challenges does the job present? Theresa Pietz provides fascinating insights into her duties, motivations and experiences working with animals.

What is actually happening behind the scenes of a patient trial? Anna Ruzhyna is a clinical research associate who looks after participants with heart failure as part of the HI-FIVE project. She explains how her work helps to develop new therapeutic approaches for the treatment of heart failure.

How can new therapeutic approaches for heart failure be developed more effectively? Stem cell research plays a central role in the HI-FIVE project. In this interview, PD Dr Anna Klinke (Herz- und Diabeteszentrum NRW) talks about her work between the lab and the clinic. She explains how the versatility of stem cells enables heart and vascular cells to be obtained from individual patients' blood and why this is an important step in investigating the specific effects of new active substances.

What changes take place in heart muscle cells when a left ventricular assist device is used? ISAS doctoral student Kevin Hau (28) is tackling this question by researching the consequences of heart attacks using various omics analyses.

Felix Hormann is spending three months conducting research at the University of Copenhagen. In this interview, the ISAS doctoral student discusses the new perspective he has gained on his lipid research and his exciting day-to-day life as a scientist in Denmark.

How are new therapeutic approaches being developed to close the gap in the treatment of patients with heart failure? And what knowledge from clinical practice is crucial for this? Prof. Dr Tanja Rudolph provides insights into her daily work as a cardiologist and talks about her role in the translational research project HI-FIVE, and the future of cardiovascular disease therapy.
