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Advancing Analytics

We develop and combine technologies into four-dimensional analytical methods for health research. Our goal: With our analytics for precision medicine, we want to contribute to optimising the prevention, diagnosis and therapy of various diseases.

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Research Programmes

In our four programmes, we conduct research on various interdisciplinary projects. In one of our research programmes, for example, we combine analytical procedures and develop multi-method concepts in order to elucidate disease mechanisms and identify potential therapeutic approaches - always with a clear application purpose for the following preclinical research.

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ISAS Kompakt

8th September 2025

3 Questions for Susmita Ghosh

How does gut microbiota affect the immune system? Susmita Ghosh conducts research on proteins and immune cells at ISAS. In this interview, the biologist talks about her work and explains how gut flora and the immune system could affect the outcomes of a stroke.

Susmita Ghosh sitzt am ultrasensitiven Massenspektrometer und stellt eine Proben ein.
8th September 2025

Gut Flora & Stroke: How Microorganisms Influence Our Immune System

Which factors can activate immune cells after a stroke? This question was investigated by researchers at University Hospital Essen and ISAS. Their work focused on the gut microbiota.

23rd July 2025

3 Questions for Dr Ali Ata Tuz

In his doctorate, Dr Ali Ata Tuz researched the causes of immunodeficiency after strokes and was already working closely with ISAS at the time. Following this, he subsequently devoted himself to the behaviour of immune cells in the bioimaging research group at ISAS. In this interview, the physician talks about his path from the clinic to application-oriented basic research.

Dr. Ali Ata Tuz sitzt am Konfokalmikroskop und schaut frontal in die Kamera.. Auf dem Bildschirm nebem dem Mirkoskop sind in grün und violett Mikroskopaufnahmen von einer Probe im Mikroskop zu sehen.
8th July 2025

Heart Failure Rarely Occurs on Its Own: ISAS Researchers Develop New Treatment Pillars

The symptoms, subsequent problems and therapeutic challenges of patients with heart failure are increasingly challenging for general practitioners and cardiologists. Doctors are limited in their choice of treatment options, especially for patients with additional diseases. At ISAS, researchers are therefore focussing on broadening the therapeutic spectrum.

Prof. Dr. Kristina Lorenz.
25th June 2025

New Ionisation Method: From Open Questions to Closed Plasma

Mass spectrometry only works with electrically charged, i.e. ionised, particles. Researchers often use plasma for this purpose. In a series of publications, scientists from the Miniaturisation Research Group have shed new light on this ionisation method and presented a completely new type of plasma. This does not require a continuous gas flow and is therefore particularly resource-efficient.

Cayian Tian adjusts the gas supply to the plasma.
11th June 2025

“We essentially ask ourselves the same questions”

In the ISAS cooperation project “The Secret World of the Immune System”, ISAS researchers and artists from the storyLab kiU at Dortmund University of Applied Sciences and Arts brought microscope data to life in an immersive space. Lennart Oberscheidt, research associate and visual effects (VFX) supervisor at storyLab kiU, talks about the special features of the project and the similarities between art and research in an interview.

30th May 2025

What Can't Be Missing From Your Project, Laxmikanth Kollipara?

In many research projects, there is one thing that is essential for success. Perhaps a rare sample or a special device? For Dr Laxmikanth Kollipara, that one thing is a very special pillar from the PIPMet project.

Dr Laxmikanth Kollipara stands in the laboratory holding a silver-coloured column. In the background are HPLC systems.
14th May 2025

“Moving to ISAS changed my whole view on mass spectrometry”

Prof Dr Miloš Filipović is researching the connection between ageing processes and gasotransmitter signalling pathways, in particular hydrogen sulphide. The biochemist headed the ERC Sulfaging group at ISAS from October 2020 until February 2025, at which point he was appointed to the University of Glasgow in Scotland. In this interview, he looks back on the past four and a half years in Dortmund and talks about his experiences at ISAS.

Dr. habil. Milos Filipovic.
30th April 2025

Humboldt Fellow Prof Dr Xiaowei Xu started at ISAS in March

Prof Dr Xiaowei Xu from the Chinese Guangdong Cardiovascular Institute is researching the clinical application of artificial intelligence (AI) in the context of cardiovascular diseases. For 18 months in total, he will be researching various AI methods for analysing cell images as a Humboldt Fellow at ISAS.

Prof Dr Xiaowei Xu in front of the ISAS city building.
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Publications

Analytical Chemistry, Vol. 97, No. 32, 2025, P. 17512-17520

Chen S, Sanner MF, Gracias Leone D, Loroch S, Forli S, Verhelst SHL.

Sulfoxide-diazirine (SODA) as a Cleavable Photoaffinity Group To Enable the Identification of Photolabeled Modification Sites via LC-MS³

https://doi.org/10.1021/acs.analchem.5c02409

Proteomics, Vol. 2025, No. 16, 2025, P. 28-39

Li T, Wenger A, Coman C, Borutzki C, Kreutz MR, Ahrends R.

SIMPLEX Enriches Hydrophobic and Lipidated Proteins in Membrane Proteomics Experiments

https://doi.org/10.1002/pmic.70016

G3-Genes Genomes Genetics, Vol. 15, No. 8, 2025

Valenzuela-Villatoro M, Gomez-Orte E, Guerrero-Gomez D, Cheng Q, Zheleva A, Mora-Lorca JA, Petrovic D, O'Neil NJ, Ceron J, Hatakeyama A, Onami S,…

The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans

https://doi.org/10.1093/g3journal/jkaf102

THIRTY-NINTH AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE, Vol. 39, No. 10, 2025, P. 10284-10292

Zhang Y, Fang Z, Wang Y, Zhang L, Guan X, Zhang Y.

Category Prompt Mamba Network for Nuclei Segmentation and Classification

https://doi.org/10.1609/aaai.v39i10.3311

Hepatology Communications, Vol. 9, No. 8, 2025

Panzeri D, Di Tommaso L, Sironi L.

Reply: Diagnostic accuracy of ChatGPT-4 and liver fibrosis in MASH

https://doi.org/10.1097/HC9.0000000000000764

Orphanet Journal of Rare Diseases, Vol. 20, No. 1, 2025

Paul L, Schaenzer A, Depienne C, Hentschel A, Kohlschmidt N, Schara-Schmidt U, Nelke CJ, Roos A, Koelbel H.

Lessons learned from a muscle study in nail-patella syndrome

https://doi.org/10.1186/s13023-025-03911-0

Analytical and Bioanalytical Chemistry, Vol. 417, No. 22, 2025, P. 5037-5046

Fechner A, Drees C, Vautz W, Sielemann S, Telgheder U, Franzke J, Brandt S.

Seamless analysis of liquid samples by coupling a thermal desorption chip with ion mobility spectrometry

https://doi.org/10.1007/s00216-025-06023-7

PLOS One, Vol. 2025, No. 7, 2025

Walke D, Steinbach D, Gibb S, Kaiser T, Saake G, Ahrens PC, Broneske D, Heyer R.

Edges are all you need: Potential of medical time series analysis on complete blood count data with graph neural networks

https://doi.org/10.1371/journal.pone.0327636

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