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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Water Research, Vol. 292, No. 292, 2025, P. 125272
Hellwig P, Seick I, Meinusch N, Benndorf D, Wiese J, Reichl U, Heyer R.
Molecular community data meets anaerobic digestion Model 1 (ADM1) - a study about the correlation between metagenome-centric metaproteomics data of a two-step full-scale anaerobic digester and its corresponding mathematical model
https://doi.org/10.1016/j.watres.2025.125272
American Journal of Physiology - Heart and Circulatory Physiology, Vol. 330, No. 3, 2026, P. H854-H868
Eickelmann C, Gedik N, Lieder HR, Kollipara L, Sickmann A, Sturek M, Heusch G, Kleinbongard P.
Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs
https://doi.org/10.1152/ajpheart.00905.2025
British Journal of Pharmacology , Vol. 183, No. 5, 2025, P. 990-1008
Klapproth E, Marks J, Diaba-Nuhoho P, Grell S, Leubauer P, Kämmerer S, Soltwedel JR, Rasmussen F, Mejia F, Moss ML, Prince C, Mirtschink P, Wielockx…
Leveraging the ADAM10 prodomain for selective inhibition to enhance recovery after myocardial infarction
https://doi.org/10.1111/bph.70201
Trends in Molecular Medicine, Vol. 32, No. 3, 2025, P. 231-255
Schanbacher C, Goebeler M, Gerull B, Lorenz K.
Targeting pathological ERK1/2 signaling in cancer and beyond
https://doi.org/10.1016/j.molmed.2025.08.001
Clinical and Experimental Medicine, Vol. 26, No. 1, 2026
Lang A, Pang TY, Piel S, Oehler D, Zweck E, Shahrjerdi K, Okkasian M, Georgy J, Reinders Y, Duplessis A, Tank J, Jordan J, Pfeiler S, Sickmann A,…
Oxygen-dependent modulation of the human complement system during acute normobaric hypoxia: a translational plasma proteomics study
https://doi.org/10.1007/s10238-026-02084-9
Cancer cell, Vol. 44, No. 1, 2025, P. 94-111.e11
Guo W, Luan J, Huang X, Leon D, Gang S, Nicholson B, Bertacchi B, Bolotin D, Lingen MW, Pearson AT, Izumchenko E, Rosenberg AJ, Agrawal N, Vokes EE,…
Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche
https://doi.org/10.1016/j.ccell.2025.11.001
Clinical Genetics, Vol. 2026, 2026
Kilicarslan OA, Gangfuß A, Hentschel A, Koelbel H, Muhmann D, Töpf A, Stöhr M, Chen L, Horvath R, Thompson R, Schara-Schmidt U, Kurth I, Lochmüller…
A Homozygous CPSF1 Variant Causes Congenital Cataract, Intellectual Disability and Hyperphagia
https://doi.org/10.1111/cge.70130
Journal of Proteome Research, Vol. 2025, 2025, P. 484-490
Lange E, Schallert K, Schwerdt J, Ghosh S, Hentschel A, Reinders Y, Heyer R.
The Omics Molecule Extractor: A Web Application for the Selection of Potential Biomarker Panels
https://doi.org/10.1021/acs.jproteome.5c00176