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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Analytica Chimica Acta, Vol. 343946, No. 2025, 2025
Fechner A, Höving S, Schiller A, Telgheder U, Franzke J.
Instrumental developments in drift tube ion mobility spectrometry: A review on miniaturization, new manufacturing techniques, and pre-separation
https://doi.org/10.1016/j.aca.2025.343946
Journal of Materials Science, 2025
Al-Bataineh QM, Aljarrah I, Ahmad AA, Rjoub G, Telfah AD, Hergenroeder R.
Surface plasmon coupling between different shapes of silver nanostructures and wide-field SPR microscopy
https://doi.org/10.1007/s10853-025-10917-3
Circulation Research, Vol. 136, No. 10, 2025, P. 1110-1112
Altieri D, Lorenz K, Epelman S.
New Minimally Invasive Myocardial Ischemia/Reperfusion Approach
https://doi.org/10.1161/CIRCRESAHA.125.326461
Journal of Proteome Research, 2025
Smith KW, Fecke A, Kasarla SS, Phapale P.
Large-scale metabolite imaging gallery of mouse organ tissues to study spatial metabolism
https://doi.org/10.21203/rs.3.rs-3891634/v1
Nature Communications, Vol. 16, No. 1, 2025
Müller M, Schubert T, Welke C, Maske T, Patschowski T, Donhauser E, Heinen-Weiler J, Hormann F, Heiles S, Schulz TJ, Lengenfelder LA, Landwehrjohann…
Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice
https://doi.org/10.1038/s41467-025-59192-5
Scientific Data, Vol. 2025, No. 12, 2025, P. 596
Siemes D, Voss H, Benvenuti F, Simoncello F, Kopczynski D, Siebels B, Schlüter H, Kollipara L, Sickmann A, Engel DR, Shevchuk O.
A reference database enabling in-depth proteome and PTM analysis of mouse immune cells
https://doi.org/10.1038/s41597-025-04829-9
PeerJ Computer Science, 2025
Bershadskyy D, Krüger J, Çalikli G, Otto S, Zabel S, Greif J, Heyer R.
A Laboratory Experiment on Using Different Financial-Incentivization Schemes in Software-Engineering Experimentation
https://doi.org/10.48550/arXiv.2202.10985
Communications Medicine, Vol. 2025, No. 5, 2025
Mill L, Aust O, Ackermann JA, Burger P, Pascual M, Palumbo-Zerr K, Krönke G, Uderhardt S, Schett G, Clemen CS, Holtzhausen C, Jabari S, Schröder R,…
Deep learning-based image analysis in muscle histopathology using photo-realistic synthetic data
https://doi.org/10.1038/s43856-025-00777-y