-
The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
-
The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Analytical Chemistry, Vol. 97, No. 32, 2025, P. 17512-17520
Chen S, Sanner MF, Gracias Leone D, Loroch S, Forli S, Verhelst SHL.
Sulfoxide-diazirine (SODA) as a Cleavable Photoaffinity Group To Enable the Identification of Photolabeled Modification Sites via LC-MS³
https://doi.org/10.1021/acs.analchem.5c02409
Proteomics, Vol. 2025, No. 16, 2025, P. 28-39
Li T, Wenger A, Coman C, Borutzki C, Kreutz MR, Ahrends R.
SIMPLEX Enriches Hydrophobic and Lipidated Proteins in Membrane Proteomics Experiments
https://doi.org/10.1002/pmic.70016
G3-Genes Genomes Genetics, Vol. 15, No. 8, 2025
Valenzuela-Villatoro M, Gomez-Orte E, Guerrero-Gomez D, Cheng Q, Zheleva A, Mora-Lorca JA, Petrovic D, O'Neil NJ, Ceron J, Hatakeyama A, Onami S,…
The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans
https://doi.org/10.1093/g3journal/jkaf102
THIRTY-NINTH AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE, Vol. 39, No. 10, 2025, P. 10284-10292
Zhang Y, Fang Z, Wang Y, Zhang L, Guan X, Zhang Y.
Category Prompt Mamba Network for Nuclei Segmentation and Classification
https://doi.org/10.1609/aaai.v39i10.3311
Hepatology Communications, Vol. 9, No. 8, 2025
Panzeri D, Di Tommaso L, Sironi L.
Reply: Diagnostic accuracy of ChatGPT-4 and liver fibrosis in MASH
https://doi.org/10.1097/HC9.0000000000000764
Orphanet Journal of Rare Diseases, Vol. 20, No. 1, 2025
Paul L, Schaenzer A, Depienne C, Hentschel A, Kohlschmidt N, Schara-Schmidt U, Nelke CJ, Roos A, Koelbel H.
Lessons learned from a muscle study in nail-patella syndrome
https://doi.org/10.1186/s13023-025-03911-0
Analytical and Bioanalytical Chemistry, Vol. 417, No. 22, 2025, P. 5037-5046
Fechner A, Drees C, Vautz W, Sielemann S, Telgheder U, Franzke J, Brandt S.
Seamless analysis of liquid samples by coupling a thermal desorption chip with ion mobility spectrometry
https://doi.org/10.1007/s00216-025-06023-7
PLOS One, Vol. 2025, No. 7, 2025
Walke D, Steinbach D, Gibb S, Kaiser T, Saake G, Ahrens PC, Broneske D, Heyer R.
Edges are all you need: Potential of medical time series analysis on complete blood count data with graph neural networks
https://doi.org/10.1371/journal.pone.0327636