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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Scientific Data, Vol. 2025, No. 12, 2025
Siemes D, Voss H, Benvenuti F, Simoncello F, Kopczynski D, Siebels B, Schlüter H, Kollipara L, Sickmann A, Engel DR, Shevchuk O.
A reference database enabling in-depth proteome and PTM analysis of mouse immune cells
https://doi.org/10.1038/s41597-025-04829-9
Nature Metabolism, Vol. 7, No. 3, 2025, P. 531-555
Zuhra K, Petrosino M, Janickova L, Petric J, Ascenção K, Vignane T, Khalaf M, Philipp TM, Ravani S, Anand A, Martins V, Santos S, Erdemir S, Malkondu…
Regulation of mammalian cellular metabolism by endogenous cyanide production
https://doi.org/10.1038/s42255-025-01225-w
Applied Surface Science, Vol. 682, 2025
Al-Bataineh Q, Rjoub G, Telfah AD, Ahmad AA, Tavares CJ, Hergenröder R.
Developing surface plasmon resonance imaging for discrete particle detection based on a silver layer coated with polyacrylic acid/iodine polyelectrolyte brushes
https://doi.org/10.1016/j.apsusc.2024.161755
Journal of leukocyte biology, Vol. 117, No. 2, 2025
Cibir Z, Beer A, Kraus A, Pillibeit A, Bludau D, Abdulla H, Neuendorff NR, Sonneck J, Kowitz L, Riese S, Tuz A, Chen J, Cherneha M, Beelen DW,…
Risk beyond neutropenia: insights into neutrophil migration from newly diagnosed AML until late after allogeneic stem cell transplantation
https://doi.org/10.1093/jleuko/qiae250
Acta Neuropathologica Communications, Vol. 13, No. 1, 2025
Della Marina A, Koutsoulidou A, Natera-de Benito D, Tykocinski L, Tomazou M, Georgiou K, Laner A, Kölbel H, Nascimento A, Ortez C, Abicht A, Thakur…
Blood biomarker fingerprints in a cohort of patients with CHRNE-related congenital myasthenic syndrome
https://doi.org/10.1186/s40478-025-01946-9
Journal of Neuroinflammation, Vol. 22, No. 1, 2025
Christ R, Siemes D, Zhao S, Widera L, Spangenberg P, Lill J, Thiebes S, Bottek J, Borgards L, Pinho AG, Silva NA, Monteiro S, Jorch SK, Gunzer M,…
Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology
https://doi.org/10.1186/s12974-025-03356-z
Cell Metabolism, Vol. 2025, No. 37(2), 2025, P. 542-556.e14
Petrovic D, Slade L, Paikopoulos Y, D'Andrea D, Savic N, Stancic A, Miljkovic JL, Vignane T, Drekolia MK, Mladenovic D, Sutulovic N, Refeyton A,…
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation
https://doi.org/10.1016/j.cmet.2024.12.008
Biomedizinische Technik / Biomedical engineering, Vol. 70, No. 1, 2024, P. 71-90
Li J, Zhou Z, Yang J, Pepe A, Gsaxner C, Luijten G, Qu C, Zhang T, Chen X, Li W, Wodzinski M, Friedrich P, Xie K, Jin Y, Ambigapathy N, Nasca E,…
MedShapeNet - a large-scale dataset of 3D medical shapes for computer vision.
https://doi.org/10.1515/bmt-2024-0396