-
The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
-
The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Redox Biology, Vol. 96, 2026, P. 104304
Refeyton A, Amoedo ND, Labat V, Vignane T, Bure C, Pinson B, Ley-Ngardigal S, Debeissat C, Bursac B, Claverol S, Khelifi R, Rodriguez L, de la Grange…
Aglycemia triggers alternative electron transport to sustain mesenchymal stem cell survival under anoxia
https://doi.org/10.1016/j.redox.2026.104304
ACS Measurement Science Au, Vol. 6, No. 4, 2026, P. 1194-1205
Hormann F, Heiles S.
Quantitative MALDI-MSI Workflow for Lipids with a LC-MS-Based Quality Control Pipeline
https://doi.org/10.1021/acsmeasuresciau.6c00083
Journal of Neuropathology and Experimental Neurology, 2026
Kolbel H, Hentschel A, Preusse C, Tiet M, Dohrn MF, Muhmann D, van den Ameele J, Chen L, Schara-Schmidt U, Weis J, Horvath R, Mensch A, Roos A.
When muscles matter in SORD neuropathy
https://doi.org/10.1093/jnen/nlag057
Nature structural & molecular biology, Vol. 33, No. 8, 2026, P. 1252-1265
Vignane T, Hugo M, Hoffmann C, Reichert P, Katsouda A, D'Andrea D, Wang H, Tromm JV, Miler M, Comas F, Petrovic D, Chen S, Miljkovic JL, Stoychev D,…
Protein thiol alterations drive pathologic liquid-liquid phase separation in the aging brain
https://doi.org/10.1038/s41594-026-01857-w
Nanomaterials, Vol. 16, No. 15, 2026
Jänicke P, Ebersbach P, Pantelic ND, Cengic S, Freier E, Wessjohann LA, Milanovic Z, Kaluderovic GN.
Surface-Directed Regulation of Intracellular Trafficking and Apoptotic Pathways by Fluorescent SBA-15 Nanocarriers Governs the Intracellular Fate of Emodin
https://doi.org/10.3390/nano16150905
Microbiome, Vol. 14, No. 1, 2026
Van den Bossche T, Grenga L, Alves G, Arntzen MO, Benndorf D, Brauer M, Figeys D, Henry C, Hettich RL, Heyer R, Jagtap PD, Jehmlich N, Kleiner M, Li…
The Metaproteomics Initiative: five years of community-driven progress
https://doi.org/10.1186/s40168-026-02463-0
Microbiome, Vol. 14, No. 1, 2026
van den Bossche T, Wolf M, Armengaud J, Arntzen MO, Benndorf D, Figeys D, Grenga L, Hettich RL, John NS, Jagtap P, Jehmlich N, Kleiner M, Kunath BJ,…
The need for standardization and improved open (meta)data practices in metaproteomics
https://doi.org/10.1186/s40168-026-02455-0
Analytical Chemistry, Vol. 98, No. 28, 2026, P. 20725-20737
Dierks J, Brockmann EU, Arias-Loza A, Bocklitz T, Nordbeck P, Lorenz K, Tolstik E, Heiles S.
Automatic Coregistration of High-Resolution MALDI-MSI and Raman Imaging Applied to Cardiac Tissue of Fabry Disease Mouse Models
https://doi.org/10.1021/acs.analchem.5c07622