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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
BioTechniques, Vol. 78, No. 1-12, 2026, P. 323-343
Cao K, Gao C, Zhang X, Pan X, Chen J, Wang H.
Recent advances in deep learning for biological microscopy image analysis beyond segmentation
https://doi.org/10.1080/07366205.2026.2730974
Redox Biology, Vol. 96, 2026, P. 104304
Refeyton A, Amoedo ND, Labat V, Vignane T, Bure C, Pinson B, Ley-Ngardigal S, Debeissat C, Bursac B, Claverol S, Khelifi R, Rodriguez L, de la Grange…
Aglycemia triggers alternative electron transport to sustain mesenchymal stem cell survival under anoxia
https://doi.org/10.1016/j.redox.2026.104304
Science, Vol. 393, No. 6818, 2026, P. 1-18
Goswami S, Zhang Q, Yildiz AB, Das Adhikari U, Raghawan AK, Bulliard M, Sedhain S, Darawshi O, Celik CE, Cansiz F, Krempe CP, Rösler J, Allies G,…
Ceramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program
https://doi.org/10.1126/science.adw8520
ACS Chemical Biology, Vol. 21, No. 9, 2026, P. 2232–2243
Amma MM, Kollipara L, Dürr-Mayer T, Streeck J, Schmieder P, Saiardi A, Jessen HJ, Heiles S, Fiedler D.
Isotopic Tracing of [13C6]scyllo-Inositol Uncovers Its Incorporation into Phosphatidylinositols in Immortalized Mammalian Cells
https://doi.org/10.1021/acschembio.6c00409
Biomolecular NMR assignments, Vol. 20, No. 1, 2026
Auch J, Peddinghaus AC, Stoll R.
Backbone and side chain 1H, 13C and 15N chemical shift assignment of the cargo-recognition domain MOTH of human TANGO1
https://doi.org/10.1007/s12104-026-10278-1
Advanced Science, Vol. 13, No. 52, 2026, P. e76236
Jung M, Beer A, Ghosh S, Pylaeva E, Alshaar B, Tertel T, Leimkühler NB, Schroeder T, Gronewold J, Hagemann N, Mohamud Yusuf A, Frank B, Zhang Y,…
CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity
https://doi.org/10.1002/advs.76236
ACS Measurement Science Au, Vol. 6, No. 4, 2026, P. 1194-1205
Hormann F, Heiles S.
Quantitative MALDI-MSI Workflow for Lipids with a LC-MS-Based Quality Control Pipeline
https://doi.org/10.1021/acsmeasuresciau.6c00083
Journal of Neuropathology and Experimental Neurology, 2026
Kolbel H, Hentschel A, Preusse C, Tiet M, Dohrn MF, Muhmann D, van den Ameele J, Chen L, Schara-Schmidt U, Weis J, Horvath R, Mensch A, Roos A.
When muscles matter in SORD neuropathy
https://doi.org/10.1093/jnen/nlag057