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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Analytica Chimica Acta, Vol. 2025, No. 1356, 2025
Fechner A, Höving S, Schiller A, Telgheder U, Franzke J.
Instrumental developments in drift tube ion mobility spectrometry: A review on miniaturization, new manufacturing techniques, and pre-separation
https://doi.org/10.1016/j.aca.2025.343946
International Journal of Mass Spectrometry, Vol. 515, 2025
Yu J, Heiles S.
Structure selective fragment ions of epoxidized sphingolipids
https://doi.org/10.1016/j.ijms.2025.117483
Analytical and Bioanalytical Chemistry, 2025
Yu J, Alshaar B, Heiles S.
Comprehensive lipid structure annotation via photochemical epoxidation and mass spectrometry
https://doi.org/10.1007/s00216-025-05953-6
G3-genes Genomes Genetics, 2025
Valenzuela-Villatoro M, Gomez-Orte E, Guerrero-Gomez D, Cheng Q, Zheleva A, Mora-Lorca JA, Petrovic D, O'Neil NJ, Ceron J, Hatakeyama A, Onami S,…
The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans
https://doi.org/10.1093/g3journal/jkaf102
Analytical Chemistry, 2025
Saw NMMT, Kowitz L, Lampen P, Kasarla SS, Fecke A, Chen J, Phapale P.
MSI-Explorer: Napari-Powered Tool for Mass Spectrometry Imaging Data Analysis
https://doi.org/10.1021/acs.analchem.5c01513
Redox Biology, Vol. 83, 2025
Smimmo M, Casale V, D'Andrea D, Bello I, Iaccarino N, Romano F, Brancaleone V, Panza E, d'Emmanuele di Villa Bianca R, Katsouda A, Mitidieri E,…
Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1
https://doi.org/10.1016/j.redox.2025.103645
Spectrochimica Acta Part B-Atomic Spectroscopy, Vol. 228, 2025
Tian C, Speicher L, Song H, Ahlmann N, Brandt S, Niu G, Franzke J.
Study of the discharge mode transition in a Ne-flexible micro-tube plasma (FμTP)
https://doi.org/10.1016/j.sab.2025.107180
Microbiome, Vol. 13, No. 1, 2025
Heyer R, Wolf M, Benndorf D, Uzzau S, Seifert J, Grenga L, Pabst M, Schmitt H, Mesuere B, Van Den Bossche T, Haange S, Jehmlich N, Di Luca M, Ferrer…
Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes
https://doi.org/10.1186/s40168-025-02119-5