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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
American journal of physiology. Heart and circulatory physiology, Vol. 330, No. 3, 2026, P. H854-H868
Eickelmann C, Gedik N, Lieder HR, Kollipara L, Sickmann A, Sturek M, Heusch G, Kleinbongard P.
Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs
https://doi.org/10.1152/ajpheart.00905.2025
Trends in Molecular Medicine, Vol. 32, No. 3, 2025, P. 231-255
Schanbacher C, Goebeler M, Gerull B, Lorenz K.
Targeting pathological ERK1/2 signaling in cancer and beyond
https://doi.org/10.1016/j.molmed.2025.08.001
Cancer cell, Vol. 44, No. 1, 2025, P. 94-111.e11
Guo W, Luan J, Huang X, Leon D, Gang S, Nicholson B, Bertacchi B, Bolotin D, Lingen MW, Pearson AT, Izumchenko E, Rosenberg AJ, Agrawal N, Vokes EE,…
Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche
https://doi.org/10.1016/j.ccell.2025.11.001
Journal of Proteome Research, Vol. 2025, 2025, P. 484-490
Lange E, Schallert K, Schwerdt J, Ghosh S, Hentschel A, Reinders Y, Heyer R.
The Omics Molecule Extractor: A Web Application for the Selection of Potential Biomarker Panels
https://doi.org/10.1021/acs.jproteome.5c00176
Proteomics. Clinical applications, Vol. 20, No. 1, 2025
Thilmany S, Thomas A, Reinders Y, Shakeri F, Vogel M, Sickmann A, Scholl C, Thevis M.
Hormonal Contraceptives and Depression: A Proteomic Analysis Using Neuronal Models
https://doi.org/10.1002/prca.70017
BMC Medicine, Vol. 2025, No. 23, 2025
Sehgal R, Haacke N, Maguolo A, Solari FA, Jähnert M, Gottmann P, Nilsson E, Vaag A, Fischer-Posovszky P, Werberger A, Birkenfeld AL, Fritsche A,…
Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes
https://doi.org/10.1186/s12916-025-04560-7
Coral Reefs, 2025
Stuhr M, Kollipara L, Reymond CE, de Beer D, Ries J, Sickmann A, Westphal H.
Differing proteome responses to ocean acidification between two common pocilloporid corals
https://doi.org/10.1007/s00338-025-02801-y
Journal of Clinical Medicine, Vol. 14, No. 24, 2025
Aksel Kilicarslan O, Gangfuss A, Kolbel H, Muhmann D, Polavarapu K, Thompson R, Schmitt L, Lessard L, Chen L, Eisenkolbl A, Schara-Schmidt U,…
Combined Histological and Proteomic Analysis Reveals Muscle Denervation in KMT5B-Related Neurodevelopmental Disorder: A Case Report
https://doi.org/10.3390/jcm14248636