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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Journal of Proteomics, Vol. 318, 2025
Wolf M, Lange J, Benndorf D, Welz L, Nikolaus S, Siever LK, Tran F, Schallert K, Hellwig P, Schreiber S, Gunzer M, Rosenstiel P, Reichl U, Adolph T,…
Fecal metaproteomics enables functional characterization of remission in patients with inflammatory bowel disease
https://doi.org/10.1016/j.jprot.2025.105455
RSC Advances, Vol. 15, No. 27, 2025, P. 21890-21897
Prymak O, Breisch M, Loza K, Heggen M, Köller M, Sengstock C, Epple M.
Enhanced dissolution of silver nanoparticles (10 nm) in the presence of platinum nanoparticles (3 nm) causes increased cytotoxicity: mechanistic insight via transmission electron microscopy and X-ray powder diffraction
https://doi.org/10.1039/D5RA02579F
Analytica Chimica Acta, Vol. 1356, No. 1356, 2025
Fechner A, Höving S, Schiller A, Telgheder U, Franzke J.
Instrumental developments in drift tube ion mobility spectrometry: A review on miniaturization, new manufacturing techniques, and pre-separation
https://doi.org/10.1016/j.aca.2025.343946
International Journal of Mass Spectrometry, Vol. 515, 2025
Yu J, Heiles S.
Structure selective fragment ions of epoxidized sphingolipids
https://doi.org/10.1016/j.ijms.2025.117483
Analytical and Bioanalytical Chemistry, 2025
Yu J, Alshaar B, Heiles S.
Comprehensive lipid structure annotation via photochemical epoxidation and mass spectrometry
https://doi.org/10.1007/s00216-025-05953-6
Proteomics, 2025, P. e70003
Behnke J, Hentschel A, Wolf M, Wycisk V, Sickmann A, Heyer RS, Urner LH.
Detergent Screening With Hybrid Detergents Increases Observable Number of Protein Identities in Bottom-Up Proteomics
https://doi.org/10.1002/pmic.70003
G3-Genes Genomes Genetics, 2025
Valenzuela-Villatoro M, Gomez-Orte E, Guerrero-Gomez D, Cheng Q, Zheleva A, Mora-Lorca JA, Petrovic D, O'Neil NJ, Ceron J, Hatakeyama A, Onami S,…
The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans
https://doi.org/10.1093/g3journal/jkaf102
Aging-US, Vol. 17, No. 6, 2025, P. 1429-1451
Liang Y, Krivograd A, Hofer SJ, Kollipara L, Züllig T, Sickmann A, Eisenberg T, Sigrist SJ.
Spermidine supplementation and protein restriction protect from organismal and brain aging independently
https://doi.org/10.18632/aging.206267