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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Chemistry-A European Journal, Vol. 30, No. 56, 2024, P. e202402685
Squarcina A, Maier P, Senft L, Vignane T, Filipovic MR, Ivanovic-Burmazovic I.
Unlocking Selective Anticancer Mechanisms: Dinuclear Manganese Superoxide Dismutase Mimetics Combined with Pt(II) Complexes
https://doi.org/10.1002/chem.202402685
JMIR Serious Games, Vol. 12, 2024, P. e52785
Egger J, Gsaxner C, Luijten G, Chen J, Chen X, Bian J, Kleesiek J, Puladi B.
Is the Apple Vision Pro the Ultimate Display? A First Perspective and Survey on Entering the Wonderland of Precision Medicine
https://doi.org/10.2196/52785
Journal of Neuromuscular Diseases, Vol. 11, No. 5, 2024, P. 1131-1137
Roos A, Häusler M, Kollipara L, Topf A, Preusse C, Stucka R, Nolte K, Strom T, Berutti R, Jiang X, Koll R, Lochmüller H, Schacht SM, Zahedi RP, Weis…
HNRNPA1 de novo Variant Associated with Early Childhood Onset, Rapidly Progressive Generalized Myopathy
https://doi.org/10.3233/JND-240050
Spectrochimica Acta Part B-Atomic Spectroscopy, Vol. 219, 2024
Song H, Tian C, Speicher L, Ahlmann N, Brandt S, Niu G, Franzke J.
Elucidation of discharge mechanisms in He- and Ar-flexible μ-tube plasmas by temporally and spatially resolved plasma optical emission phoresis spectroscopy
https://doi.org/10.1016/j.sab.2024.107014
Cardiovascular Research, Vol. 2024, No. cvae169, 2024
Reyat JSS, Sommerfeld LC, O’Reilly M, Cardoso VR, Thiemann E, Khan A, O’Shea C, Harder S, Müller C, Barlow J, Stapley RJ, Chua W, Kabir SN,…
PITX2 deficiency leads to atrial mitochondrial dysfunction
https://doi.org/10.1093/cvr/cvae169
Nature Methods, Vol. 21, No. 8, 2024, P. 1390-1393
Zhang S, Dai G, Huang T, Chen J.
Multimodal large language models for bioimage analysis
https://doi.org/10.1038/s41592-024-02334-2
MMW Fortschritte der Medizin, Vol. 166, No. 13, 2024, P. 44-47
Lorenz K, Knaup J.
Nach Krankenhausaufenthalt: Wie die Behandlung weiterführen?
https://doi.org/10.1007/s15006-024-4117-7
The Journal of Chemical Physics, Vol. 161, No. 4, 2024
Schäfer S, Heiles S, Schäfer R.
On the dipole moment distribution of rigid symmetric rotors
https://doi.org/10.1063/5.0217110