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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The institute's four research programmes interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Coral Reefs, 2025
Stuhr M, Kollipara L, Reymond CE, de Beer D, Ries J, Sickmann A, Westphal H.
Differing proteome responses to ocean acidification between two common pocilloporid corals
https://doi.org/10.1007/s00338-025-02801-y
Journal of Proteome Research, Vol. 2025, 2025
Lange E, Schallert K, Schwerdt J, Ghosh S, Hentschel A, Reinders Y, Heyer R.
The Omics Molecule Extractor: A Web Application for the Selection of Potential Biomarker Panels
https://doi.org/10.1021/acs.jproteome.5c00176
Npj imaging, Vol. 2025, No. 3, 2025
Pan Z, Sonneck J, Nagel D, Hasenberg A, Gunzer M, Shi Y, Chen J.
AutoQC-Bench: a diffusion model and benchmark for automatic quality control in high-throughput microscopy
https://doi.org/10.1038/s44303-025-00117-8
Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 2025, 2025
Lorenz K, Ravens U.
Finn Waagstein and the paradigm shift in the treatment of heart failure with β-adrenergic receptor antagonists (‘β-blockers’)
https://doi.org/10.1007/s00210-025-04594-x
Redox Biology, Vol. 86, 2025
Shen TK, Vignane T, Gilglioni EH, Traini L, Kalaitsidou E, Conan P, Li A, St-Pierre-Wijckmans W, Herranz JM, Elvira B, Sanchez LO, Trépo E, Deelman…
Metabolic dysfunction-associated steatohepatitis reduces hepatic H2S-producing enzymes altering persulfidome composition
https://doi.org/10.1016/j.redox.2025.103809
Acta Neuropathologica, Vol. 2025, No. 1, 2025
Stascheit F, Roos A, Schroeter CB, Thomas JK, Hahn K, Preßler H, Hentschel A, Schlotter-Weigel B, Schoser B, Ruck T, Meisel A, Stenzel W, Preusse C.
Complement profiling of sural nerves in chronic inflammatory demyelinating polyneuropathy
https://doi.org/10.1007/s00401-025-02936-w
Metabolomics, Vol. 21, No. 5, 2025
Alwahsh M, Alejel R, Hamadneh L, Aleidi SM, Marchan R, Hasan A, Jasim S, Saqallah FG, Al-Kouz S, Hussein B, Alhusban AA, Al-Hiari Y, Al-Qirim T,…
Identification of potential biomarkers of triton WR-1339 induced hyperlipidemia: NMR-based plasma metabolomics approach and gene expression analysis
https://doi.org/10.1007/s11306-025-02318-z
The Journal of Applied Laboratory Medicine, Vol. 10, No. 5, 2025, P. 1226-1240
Walke D, Steinbach D, Kaiser T, Schönhuth A, Saake G, Broneske D, Heyer R.
SBC-SHAP: Increasing the Accessibility and Interpretability of Machine Learning Algorithms for Sepsis Prediction
https://doi.org/10.1093/jalm/jfaf091