The research group aims to detect the molecular and cellular processes that underlie so-called immuno-vascular interactions under inflammatory conditions. In order to understand, for example, an infection and its corresponding immune response, the scientists look at the process from different angles.
One of the imaging techniques that the researchers use is fluorescence microscopy. This form of light microscopy includes, among others, light sheet fluorescence microscopy (LSFM). LSFM enables the scientists to determine information on different classes of molecules and their spatial distribution patterns at the same time. In addition to imaging techniques like LSFM, the researchers also work with confocal laser scanning microscopy (CLSM) and two-photon laser scanning microscopy (TPLSM). They enable a three-dimensional analysis of biological samples from a cellular to sub-cellular level.
The researchers conduct studies on animal and human samples, take measurements of intact organs and integrate artificial intelligence into their image analyses.