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The research programmes of ISAS pursue the development of various analytical methods to support cross-scale multi-parameter analysis in health research. The objective of this is to address the complex challenges in relation to analytics for personalised medicine (precision medicine).
The three research programmes of the institute interlock with one another owing to the many scientific and technological questions. The synergies resulting from the interdisciplinary collaboration benefits the research projects within a programme. Combining complementary analytical methods plays a central role in the development of new multi-method concepts for health research. In this context the focus is always on the application-specific use of analytics.
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The research programmes focus on: clarifying disease mechanisms and identifying possible treatment approaches – including application reference for subsequent pre-clinical research in both cases; identification and detection of diagnostic, prognostic and therapeutic markers; location- and time-resolved, ideally in-vivo representation of processes, from the molecular to the cellular level; non-invasive and non-destructive analysis methods.
Research Programmes
Publications
Elsevier, Vol. 2024, 2024, P. 59-65
Hinrichs K, Kratz C, Furchner A.
Hyperspectral and Time-Resolved IR Laser Polarimetry
https://doi.org/10.1016/B978-0-323-85669-0.00001-5
Elsevier, 2024, P. 360-367
Hinrichs K, Furchner A, Rappich J, Kratz C.
Optofluidic analysis of monolayers with infrared microscopy
https://doi.org/10.1016/B978-0-323-85669-0.00002-7
Elsevier, Vol. 2024, 2024, P. 514-520
Hinrichs K, Sun G, Rappich J, Furchner A.
Structure and chemical analysis in thin films by in situ IR ellipsometry
https://doi.org/10.1016/B978-0-323-85669-0.00019-2
Nature Communications, Vol. 14, No. 1, 2023, P. 3312
Dore R, Watson L, Hollidge S, Krause C, Sentis SC, Oelkrug R, Geißler C, Johann K, Pedaran M, Lyons G, Lopez-Alcantara N, Resch J, Sayk F, Iwen A,…
Resistance to thyroid hormone induced tachycardia in RTHα syndrome
https://doi.org/10.1038/s41467-023-38960-1
Academic Press Inc., Vol. 1, 2023, P. 1115-1129
Smith KW, F.Cobice D.
Chapter 50 - Vitamin D tissue distribution by mass spectrometry imaging
ISBN: 978-0-323-91386-7
https://doi.org/10.1016/B978-0-323-91386-7.00019-2
Biomedicines, Vol. 11, No. 10, 2023
Wang C, Stöckl S, Pattappa G, Schulz D, Hofmann K, Ilic J, Reinders Y, Bauer RJ, Sickmann A, Grässel S.
Extracellular Vesicles Derived from Osteogenic-Differentiated Human Bone Marrow-Derived Mesenchymal Cells Rescue Osteogenic Ability of Bone Marrow-Derived Mesenchymal Cells Impaired by Hypoxia
https://doi.org/10.3390/biomedicines11102804
Trends Biotechnol ., Vol. 2023, No. 6, 2023
Tolstik E, Lehnart SE, Soeller C, Lorenz K, Sacconi L.
Cardiac multiscale bioimaging: from nano- through micro- to mesoscales.
https://doi.org/10.1016/j.tibtech.2023.08.007
Physiological reports, Vol. 2023, No. 11(17), 2023
Künzel SR, Winter L, Hoffmann M, Kant TA, Thiel J, Kronstein-Wiedemann R, Klapproth E, Lorenz K, El-Armouche A, Kämmerer S.
Investigation of mesalazine as an antifibrotic drug following myocardial infarction in male mice
https://doi.org/10.14814/phy2.15809