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The Miniaturisation research group specialises in developing and characterising miniaturised plasma for analytical chemistry; one of the objectives of its work is to optimise the work steps involved in mass spectrometry. Reducing the plasma to a miniature scale lowers the volume of samples required and thus cuts costs and saves resources. In addition, the group works on combining different ionisation processes to enable even mixtures of molecules to be investigated in the simplest way possible.

© ISAS / Hannes Woidich

The group specialises in two ionisation processes: dielectric barrier electrospray ionisation (DB-ESI) and the plasma jet. The aim of the research is to precisely characterise these discharges and to optimise them to the extent that they can be deployed synchronously in mass spectrometry. Both methods enable a soft ionisation which does not fragment the analytes. They can thus also be deployed to analyse very large molecules.

Highlights

7th February 2024

A Long Sought-After Combination Method in Mass Spectrometry

Researchers who analyse complex samples using mass spectrometers are often faced with the challenge that the substances they contain are fundamentally different. Some are chemically polar, others are non-polar. Until now, this has required two complex separate analyses. But a researcher at ISAS has developed a method with which even less polar substances can be included in a standard mass spectroscopic analysis for polar biological substances.

Daniel Foest steht im Labor und hält ein Papier mit einer Leberprobe, die er am Massenspektrometer untersucht.
15th December 2022

Newborn Screening: Plasma-Based Ionisation for Faster Diagnosis?

When it comes to newborn screenings, every minute counts. The earlier doctors can diagnose hormonal or metabolic diseases, the better the infants' therapeutic prospects. In the interview, Dr Marcos Bouza Areces reports on his research.

Porträt Dr. Marcos Bouza Areces.
7th October 2022

“I see the future of analytics in 3D printing”

Less waste and low costs: In the interview, Dr Sebastian Brandt explains why an ion mobility spectrometer from the 3D printer can also keep up with conventionally produced devices technology-wise.

Dr. Sebastian Brandt mit seinem IMS aus dem 3D-Drucker.
19th July 2022

NACHGEFORSCHT-Podcast Episode 3: Studying as a Working-Class Child

In the third episode of our podcast, Dr Alexander Knodel talks about what helped him as his family's first academic complete his doctorate in just two and a half years. He also explains what his research has to do with lasers and ovens.

21st June 2022

NACHGEFORSCHT-Podcast Episode 2: Success with Looping Plasma

For his dissertation, Dr Sebastian Brandt researched a new, optimised ionisation source for mass spectrometry. In the ISAS’ podcast, the physicist reports on its role in health research and gives an insight into his doctorate at the institute.

Projects

Non-Radioactive Ionisation for Spectrometry & Spectroscopy (NORISC)

The objective of the »NORISC« project is to validate the Flexible microTube Plasma as an ionisation source.

Molecular Mechanisms of Cardiac Insufficiency

As part of the »Molecular Mechanisms of Cardiac Insufficiency« project, ISAS researchers are working to decode the disease mechanisms of cardiac insufficiency and identify key structures relevant to treatment at molecular level.

Fast Meat Control (FMC)

The objective of FMC is to develop a mobile measuring instrument which can be used to identify bacteria at meat-processing plants. The hand-held measuring instrument uses a method based on plasma gas chromatography-ion mobility spectrometry (Plasma-GC-IMS).

Multiomics: A systems biology approach for cardiovascular research

Current high-throughput methods for analysing proteins, nucleic acids, and metabolites are often limited to one molecule class only. This project aims to combine several omics techniques in a multimoics platform to investigate cardiovascular diseases.

Team

PD Dr. Joachim Franzke

Research Group Leader

Department: Translational Research

Research group: Miniaturisation

Portrait von PD Dr. Joachim Franzke.

Norman Ahlmann

Technical Assistant Laser Safety Officer

Department: Translational Research

Research group: Miniaturisation

Portrait von  Norman Ahlmann.

Christopher Borg

Student Assistant

Department: Translational Research

Research group: Miniaturisation

Annika Fechner

Research Associate

Department: Translational Research

Research group: Miniaturisation

Portrait von  Annika Fechner.

Daniel Foest

Research Associate

Department: Translational Research

Research group: Miniaturisation

Portrait von  Daniel Foest.

Simon Höving

Research Associate

Department: Translational Research

Research group: Miniaturisation

Portrait von  Simon Höving.

Antje Michels

Engineer

Department: Translational Research

Research group: Miniaturisation

Portrait von  Antje Michels.

Arthur Schiller

Research Associate

Department: Translational Research

Research group: Miniaturisation

Portrait von  Arthur Schiller.

Hao Song

Research Associate

Department: Translational Research

Research group: Miniaturisation

Portrait von  Hao Song.

Luisa Speicher

Research Associate

Department: Translational Research

Research group: Miniaturisation

Portrait von  Luisa Speicher.

Caiyan Tian

Research Associate

Department: Translational Research

Research group: Miniaturisation

Portrait von  Caiyan Tian.

Valentin Trögel

Student Assistant

Department: Translational Research

Research group: Miniaturisation