Oliver Ambacher Receives ISAS Prism as Thanks

The Less the Better

If neutrophil granulocytes migrate into injured tissue, for example into the brain after a stroke, they can promote chronic inflammation and cause long-term damage. In order to analyze the functional dynamics of these immune cells, millions of them are needed. A group of researchers recently developed a method that enables mass spectrometric analysis with just 1,000 neutrophils.

Prolonged Health with a Compound Found in Mushrooms?

Is an active ingredient from shiitake or oyster mushrooms able to prolong ageing health? An international team of researchers led by Dr habil. Miloš Filipović has unravelled the mechanism of action of ergothioneine. The results show how the substance improves the health of ageing animals. A human study is currently being planned.

A cause of immunodeficiency identified

After a stroke or heart attack, the immune system of those affected is often impaired. This can lead to life-threatening infections. A team of researchers from the Faculty of Medicine at the University of Duisburg-Essen, Essen University Hospital and ISAS, has now discovered a previously unknown cause for the connection between stroke, heart attack and immunodeficiency. But that's not all: the team has also identified a new treatment approach.

EfficientBioAI: New Open-Source Software Makes AI Models Lighter and Greener

Artificial intelligence has become an integral part of research. However, the better and more complex the models become, the higher their energy consumption. Researchers at ISAS and Peking University have therefore developed ready-to-use and open software that compresses existing bioimaging AI models. With the help of the new toolbox, scientists can now run their models faster and with significantly lower energy consumption.

ComplexEye & AI Enable Faster Migration Analysis of Immune Cells

How and where immune cells such as neutrophil granulocytes migrate, for instance whether they infiltrate tumours, is crucial for cancer patients. They could benefit from drugs that prevent this migration. Until now, the migration behaviour of immune cells could only be investigated using conventional video microscopy. However, researchers at the University of Duisburg-Essen and ISAS have now developed the ComplexEye. With their new microscope for the high-throughput analysis of drug substances, they are now able to analyse significantly higher numbers of neutrophils for their migration behaviour.

Chan Zuckerberg Initiative Funds Two Projects from Dortmund

To extend the image analysis platform napari, Chan Zuckerberg Initiative is funding two projects of the ISAS research groups AMBIOM - Analysis of Microscopic BIOMedical Images and Spatial Metabolomics.