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Fabry Disease: a Molecular Map of Lipids in Tissue

A new technique developed at ISAS combines Raman microscopy and mass spectrometry imaging, and it demonstrates that, for the first time, the spatial distribution of lipids can be visualised at cellular and subcellular levels – including further essential information. The new analytical method holds high potential for the diagnosis and treatment of conditions such as Fabry disease, in which molecules undergo local changes within the tissue.

Biomedical Image Analysis with AI

Dr Jianxu Chen is taking up a professorship in AI for Biomedical Analysis at the University of Duisburg-Essen. With his research group at ISAS, he is developing AI methods that can be used to comprehensively analyse enormous quantities of complex microscopy images.

It's What's Inside That Counts: Neutrophils Form Distinct Subtypes

Neutrophils can be divided into two distinct subgroups with completely different functions. The surface protein CD177 plays a decisive role in this. For the first time, researchers from the Faculty of Medicine at the University of Duisburg-Essen and ISAS have been able to demonstrate, using a new integrated proteomics and lipidomics analysis, that the molecular signatures in CD177-defined neutrophils differ significantly from one another. The presence of this surface protein has implications for disease progression, for example in head and neck tumours.