As the central endocrine organ, the thyroid gland produces hormones that are of fundamental importance for the development and function of the human organism. The special research programme ‘Local Control of Thyroid Hormone Action – LOCOTACT’, led by the University Hospital Essen, is investigating the local control of the effects of thyroid hormones in a joint research network with the University of Lübeck and the Charité – Universitätsmedizin Berlin in cooperation with the Helmholtz Zentrum Munich, the University of Leipzig and ISAS. From 2020 to 2024, the project will focus on how these control mechanisms function, particularly in the brain, heart and liver.
Thyroid hormones and ischemic heart diseases
Brain, heart and liver are starting points for many common diseases such as stroke, heart failure (cardiac insufficiency) or liver diseases (hepatopathy). The scientists at LOCOTACT aim to find new therapeutic approaches by deciphering how the transport, metabolism and mechanism of action of thyroid hormones are controlled in the organs. The researchers also explore what effects a disruption would have on these processes. Thereby, they want to find out to what extent a changed local thyroid hormone status in the organs can have a positive effect on common diseases such as “fatty liver”. For this, they want to develop strategies for a therapeutic modification of the tissue- and cell-specific thyroid hormone status and evaluate where thyroid hormones have beneficial effects in disease processes.
The aim is to use the local modulation of the thyroid hormone effect organ-specifically for the prevention and therapy of rare and common diseases. For example, the researchers at ISAS are investigating the influence of thyroid hormones in ischemic heart disease. To achieve this, they want to further explore the underlying mechanisms and assess the signal transduction pathways of thyroid hormones.
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Frontiers in Endocrinology, Vol. 15, No. 1339741, 2023, P. 1-18
Kerp H, Gassen J, Grund S, Hönes GS, Dörr S, Mittag J, Härting N, Kaiser F, Möller LC, Lorenz K, Führer D.
Cardiac recovery from pressure overload is not altered by thyroid hormone status in old mice
https://doi.org/10.1101/2023.11.17.567523
Nature Communications, Vol. 14, No. 1, 2023
Dore R, Watson L, Hollidge S, Krause C, Sentis SC, Oelkrug R, Geißler C, Johann K, Pedaran M, Lyons G, Lopez-Alcantara N, Resch J, Sayk F, Iwen A,…
Resistance to thyroid hormone induced tachycardia in RTHα syndrome
https://doi.org/10.1038/s41467-023-38960-1
Circulation Research, Vol. 132, No. 4, 2023, P. 400-414
Cachorro E, Günscht M, Schubert M, Sadek MS, Siegert J, Dutt F, Bauermeister C, Quickert S, Berning H, Nowakowski F, Lämmle S, Firneburg R, Luo X,…
CNP Promotes Antiarrhythmic Effects via Phosphodiesterase 2
https://doi.org/10.1161/CIRCRESAHA.122.322031
Nature Communications, Vol. 13, No. 1, 2022, P. 7648
Klapproth E, Witt A, Klose P, Wiedemann J, Vavilthota N, Künzel SR, Kämmerer S, Günscht M, Sprott D, Lesche M, Rost F, Dahl A, Rauch E, Kattner L,…
Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction
https://doi.org/10.1038/s41467-022-35331-0
Archives of Toxicology, Vol. 96, No. 8, 2022, P. 2341-2360
Merches K, Breunig L, Fender J, Brand T, Bätz V, Idel S, Kollipara L, Reinders Y, Sickmann A, Mally A, Lorenz K.
The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro
https://doi.org/10.1007/s00204-022-03306-1
Frontiers in Pharmacology, Vol. 13, 2022, P. 962763
Tolstik E, Gongalsky MB, Dierks J, Brand T, Pernecker M, Pervushin NV, Maksutova DE, Gonchar KA, Samsonova JV, Kopeina G, Sivakov V, Osminkina L,…
Raman and fluorescence micro-spectroscopy applied for the monitoring of sunitinib-loaded porous silicon nanocontainers in cardiac cells
https://doi.org/10.3389/fphar.2022.962763
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 25, 2022, P. e2121867119
Lee J, Olivieri C, Ong C, Masterson LR, Gomes S, Lee B, Schaefer F, Lorenz K, Veglia G, Rosner MR.
Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop
https://doi.org/10.1073/pnas.2121867119
International Journal of Molecular Science, Vol. 23, No. Special Issue , 2022
Tolstik E, Ali N, Guo S, Ebersbach P, Möllmann D, Arias Loza A, Dierks J, Schuler I, Freier E, Debus J, Baba HA, Nordbeck P, Bocklitz T, Lorenz K.
CARS Imaging Advances Early Diagnosis of Cardiac Manifestation of Fabry Disease
https://doi.org/doi: 10.3390/ijms23105345
International Journal of Molecular Sciences, Vol. 23, No. 2, 2022
Schanbacher C, Bieber M, Reinders Y, Cherpokova D, Mathejka C, Nieswandt B, Sickmann A, Kleinschnitz C, Langhauser F, Lorenz K.
ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke
Frontiers in Cardiovascular Medicine, Vol. 8, 2021
Kerp H, Hönes GS, Tolstik E, Hönes-Wendland J, Gassen J, Moeller LC, Lorenz K, Führer D.
Protective Effects of Thyroid Hormone Deprivation on Progression of Maladaptive Cardiac Hypertrophy and Heart Failure
https://doi.org/10.3389/fcvm.2021.683522
IJC Heart & Vasculature, Vol. 34, 2021, P. 100781
Pfeiffer J, Lorenz K.
Murine models for heart failure: Their creation and applicability to human still require critical and careful considerations
https://doi.org/10.1016/j.ijcha.2021.100781