Researchers on the »Imaging of Large Tissues« project are developing a workflow to combine the various microscopy imaging methods and analytical, mass spectroscopy methods.
An interdisciplinary consortium of researchers in North Rhine-Westphalia is dedicated to improving the quality of life of patients with neuromuscular diseases by developing new precision diagnostic and treatment methods. Their goal is to find suitable therapies for patients and bring these directly to their bedsides.
Researchers aim to develop post-ionisation methods using dual laser-based MSI instrumentation (MALDI-2) in the project »Imaging Tissue Metabolism with Enhanced Sensitivity of Dual Laser Mass Spectrometry«.
In a research project funded by the state government of North Rhine-Westphalia and the European Union, researchers are developing GRK5 inhibitor-based drugs for the treatment of heart failure. The enzyme GRK5 plays a key role in the deterioration of heart function. The new active substances are also designed to take gender- and age-specific aspects of the disease into account.
In the MicrobiomeProCheck project, researchers and medical professionals are investigating the role of the gut microbiome in inflammatory bowel disease. Based on these new insights, under the leadership of ISAS, the universities of Bonn, Bielefeld, and Duisburg-Essen, along with the companies Biofidus AG and Lead Discovery Center GmbH, will be developing optimised diagnostic methods and precision medicine therapies.
As part of the »Molecular Mechanisms of Cardiac Insufficiency« project, ISAS researchers are working to decode the disease mechanisms of cardiac insufficiency and identify key structures relevant to treatment at molecular level.