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Advancing Analytics

We develop and combine technologies into four-dimensional analytical methods for health research. Our goal: With our analytics for precision medicine, we want to contribute to optimising the prevention, diagnosis and therapy of various diseases.

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Research Programmes

In our three programmes, we conduct research on various interdisciplinary projects. In one of our research programmes, for example, we combine analytical procedures and develop multi-method concepts in order to elucidate disease mechanisms and identify potential therapeutic approaches - always with a clear application purpose for the following preclinical research.

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ISAS Kompakt

6th June 2024

What are you doing at ISAS, Yvonne?

What does good scientific practice actually mean? And what are the tasks of a designated ombudsperson? Dr Yvonne Reinders gives an insight into her voluntary work.

Portrait von Dr. Yvonne Reinders.
23rd May 2024

Machine learning for early warning systems in a clinical setting?

Physicians often find themselves racing against time. In most cases, the faster treatment can be provided, the better it is for patients. The diagnosis should therefore be made as early as possible. This is where artificial intelligence could come into play. An interdisciplinary team of researchers has investigated the extent to which machine learning models are suitable for analysing clinical data - for example, to predict sepsis (blood poisoning) earlier than currently possible.

Portrait von Prof. Dr. Robert Heyer.
8th May 2024

Red Alert: Students Research the Immune System at Girls' Day

What alarm bells ring when our immune system is under attack? Why do infections occur even without external invaders? And what do a heart attack and a cold have in common? These are just some of the questions that 12 schoolgirls got to the bottom of during this year's Girls' Day at ISAS.

Das Bild zeigt einen Teil der Schülerinnen zusammen mit Luisa Röbisch, Dr. Anika Grüneboom und Dr. Christiane Stiller, während sie im Labor stehen und in die Kamera schauen.
2nd May 2024

Hydrogen Sulfide: The Surprising Molecule That Regulates Life's Vital Functions & Fights Aging

Hydrogen sulfide is considered highly toxic. Nevertheless, the foul-smelling gas fulfills many vital functions in our cells. As a gasotransmitter, for example, it can transmit signals within and between cells. But hydrogen sulfide also plays an important role in the oxygen supply in the blood – as researchers led by Dr habil Miloš Filipović at ISAS recently discovered.

Porträt Dr. habil. Miloš Filipović.
28th March 2024

New “Green” Microscopy: Less Electricity, but More Information on Immune Cells in Return

Advanced technologies, such as high-resolution microscopes, produce large amounts of data. And these again consume large amounts of electricity. In addition, there are refrigerators for samples, fume cupboards and small technical devices. While ISAS is upgrading to become greener, researchers at the institute are already working on methods to make microscopy more energy-efficient in general.

Das Bild zeigt eine schematische Darstellung der Datenverarbeitung in der Mikroskopie.
13th March 2024

Cirrhosis of the Liver: Migrating Immune Cells Act as an Early Warning System

The life expectancy of patients with liver cirrhosis depends crucially on the occurrence of disease-associated complications, such as infections. Until now, however, an ability to predict these at an early stage has been lacking. A problem, often hindering doctors from administering antibiotics or even performing a liver transplant in time. Researchers at ISAS led by Prof Dr Matthias Gunzer therefore investigated the question: Could the mobility of certain immune cells be the decisive indicator of an impending deterioration in health?

27th February 2024

3 Questions for… Dr Christopher Nelke

As a participant in the Clinician Scientist programme and physician at the Clinic for Neurology at Düsseldorf University Hospital (Universitätsklinikum Düsseldorf, UKD), Dr Christopher Nelke researches neuromuscular diseases. In this interview, he talks about his two-week guest stay at ISAS and the challenges that arise between the hospital bed and research.

Das Bild zeigt Dr. Christopher Nelke im Labor. In den Händen hält er eine Probe. The picture shows Dr Christopher Nelke in the laboratory. He is holding a sample in his hands.
20th February 2024

SARS-CoV-2: The Very Latest Methods Clarify the Active Agents and the Mechanism of Action of Ancient Self-Medications

Prophylactic, soothing or even healing agents, mostly natural substances, have been known to natural medicine since ancient times. But what about viral infections? Could infusions made from sage or perilla also be used against SARS-CoV-2 infections -as a prevention or an aid to healing? An interdisciplinary team of researchers led by Prof Dr Mirko Trilling from the Faculty of Medicine at the University of Duisburg-Essen (UDE) and scientists at ISAS investigated these questions during the coronavirus pandemic.

Das Bild zeigt Prof. Dr. Mirko Trilling mit verschränkten Armen, an einer Wand lehnend. The picture shows Prof Dr Mirko Trilling with his arms folded, leaning against a wall.
7th February 2024

A Long Sought-After Combination Method in Mass Spectrometry

Researchers who analyse complex samples using mass spectrometers are often faced with the challenge that the substances they contain are fundamentally different. Some are chemically polar, others are non-polar. Until now, this has required two complex separate analyses. But a researcher at ISAS has developed a method with which even less polar substances can be included in a standard mass spectrometric analysis for polar biological substances.

Daniel Foest steht im Labor und hält ein Papier mit einer Leberprobe, die er am Massenspektrometer untersucht.
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Publications

Biotechnology for Biofuels and Bioproducts, Vol. 17, No. 1, 2024

Khesali Aghtaei H, Heyer R, Reichl U, Benndorf D.

Improved biological methanation using tubular foam-bed reactor

https://doi.org/10.1186/s13068-024-02509-1

bioRxiv, 2024, P. 1-27

Geist D, Hönes S, Grund S, Pape J, Siemes D, Spangenberg P, Tolstik E, Dörr S, Spielmann N, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Mittag J,…

Canonical and noncanonical contribution of thyroid hormone receptor isoforms alpha and beta to cardiac hypertrophy and heart rate in male mice

https://doi.org/10.1101/2023.11.24.568041

Thrombosis and Haemostasis, 2024

Zhang P, von Ungern-Sternberg S, Hastenplug L, Solari F, Sickmann A, Kuijpers M, Heemskerk JW, Walter U, Jurk K.

Multi-phased kinetics and interaction of protein kinase signaling in glycoprotein VI-induced platelet αIIbβ3 integrin activation and degranulation

https://doi.org/10.1055/a-2311-0117

Polymers, Vol. 16, No. 10, 2024

Nguyen VBC, Reut J, Rappich J, Hinrichs K, Syritski V.

Molecularly Imprinted Polymer-Based Electrochemical Sensor for the Detection of Azoxystrobin in Aqueous Media

https://doi.org/10.3390/polym16101394

Journal of Applied Polymer Science, Vol. 141, No. 17, 2024

Ahmad AA, Al-Bataineh QM, Bani-Salameh AA, Al Omari RH, Telfah A.

Self-cleaning antireflected surfaces based on treated PEO/SiO2 nanocomposite films

https://doi.org/10.1002/app.55275

Journal of Applied Polymer Science, 2024

Al-Bataineh QM, Ahmad AA, Alakhras LA, Telfah A.

pH-responsivity and photoconductivity for the organic mixed ionic electronic conductor of PANI/PSS composite films

https://doi.org/10.1002/app.55656

Sensors and Actuators A: Physical, Vol. 370, 2024

Al-Bataineh QM, Telfah AD, Tavares CJ, Hergenröder R.

Modeling and analysis of discrete particle detection in wide-field surface plasmon resonance microscopy

https://doi.org/10.1016/j.sna.2024.115266

Journal of Neuromuscular Diseases, Vol. 11, No. 3, 2024, P. 625-645

Della Marina A, Hentschel A, Czech A, Schara-Schmidt U, Preusse C, Laner A, Abicht A, Ruck T, Weis J, Choueiri C, Lochmüller H, Kölbel H, Roos A.

Novel Genetic and Biochemical Insights into the Spectrum of NEFL-Associated Phenotypes

https://doi.org/10.3233/JND-230230

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