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Portrait von Prof. Dr. Albert Sickmann.

Albert Sickmann is the Chair of ISAS’s Board of Directors and Head of the Bioanalytics department and the Proteomics research group. His research focuses on providing quantitative evidence for post-translational modifications (protein phosphorylations, degradations, etc.), protein mutations and the detection of protein networks. To be precise, the trained biochemist and his team work on analysing the activation and inhibition of thrombocytes. In addition, they develop and optimise analytical methods relating to proteome research for use in precision medicine.

Sickmann’s interest in proteomics began to emerge right from the start of his scientific career: his PhD thesis, which he wrote at Ruhr University Bochum, was titled “Proteome Analysis of Human Cerebrospinal Fluid”. After holding various positions in Würzburg at the Rudolf Virchow Centre and as a Professor of Protein Analysis, Sickmann returned to the Ruhr region in 2008 when he accepted an appointment at his alma mater. At Ruhr University Bochum, he took on the professorship for Applied Proteomics and Bioanalytics, and at the same time he became Director of the Bioanalytics department at ISAS in Dortmund. A father of two children, one of the things he appreciates about Dortmund – in addition to networking in the Rhine-Ruhr scientific region – is his favourite “black and yellow” football club.

Select publications

Scientific Data, Vol. 2025, No. 12, 2025

Siemes D, Voss H, Benvenuti F, Simoncello F, Kopczynski D, Siebels B, Schlüter H, Kollipara L, Sickmann A, Engel DR, Shevchuk O.

A reference database enabling in-depth proteome and PTM analysis of mouse immune cells

https://doi.org/10.1038/s41597-025-04829-9

Nature, Vol. 638, 2025, P. 244-250

Doglioni G, Fernández García J, Igelmann S, Altea-Manzano P, Blomme A, La Rovere R, Liu X, Liu Y, Tricot T, Nobis M, An N, Leclercq M, El Kharraz S,…

Aspartate signalling drives lung metastasis via alternative translation

https://doi.org/10.1038/s41586-024-08335-7

Pharmacological Research, Vol. 211, 2024, P. 107558

Brand T, Baumgarten BT, Denzinger S, Reinders Y, Kleindl M, Schanbacher C, Funk F, Gedik N, Jabbasseh M, Kleinbongard P, Dudek J, Szendroedi J,…

From Ca2+ dysregulation to heart failure: β-adrenoceptor activation by RKIP postpones molecular damages and subsequent cardiac dysfunction in mice carrying mutant PLNR9C by correction of aberrant Ca2+-handling

https://doi.org/10.1016/j.phrs.2024.107558

Journal of Biological Chemistry, Vol. 300, No. 12, 2024

Zou J, Zhang P, Solari F, Schönichen C, Provenzale I, Mattheij NJA, Kuijpers MJE, Rauch JS, Swieringa F, Sickmann A, Zieger B, Jurk K, Heemskerk JW.

Suppressed ORAI1-STIM1-dependent Ca2+ entry by protein kinase C isoforms regulating platelet procoagulant activity

https://doi.org/10.1016/j.jbc.2024.107899

Molecular & Cellular Proteomics, Vol. 23, No. 11, 2024

Ghosh S, Tuz AA, Stenzel M, Singh V, Richter M, Soehnlein O, Lange E, Heyer R, Cibir Z, Beer A, Jung M, Nagel D, Hermann DM, Hasenberg A, Grüneboom…

Proteomic characterization of 1000 human and murine neutrophils freshly isolated from blood and sites of sterile inflammation

https://doi.org/10.1016/j.mcpro.2024.100858