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Portrait von Prof. Dr. Albert Sickmann.

Albert Sickmann is the Chair of ISAS’s Board of Directors and Head of the Bioanalytics department and the Proteomics research group. His research focuses on providing quantitative evidence for post-translational modifications (protein phosphorylations, degradations, etc.), protein mutations and the detection of protein networks. To be precise, the trained biochemist and his team work on analysing the activation and inhibition of thrombocytes. In addition, they develop and optimise analytical methods relating to proteome research for use in precision medicine.

Sickmann’s interest in proteomics began to emerge right from the start of his scientific career: his PhD thesis, which he wrote at Ruhr University Bochum, was titled “Proteome Analysis of Human Cerebrospinal Fluid”. After holding various positions in Würzburg at the Rudolf Virchow Centre and as a Professor of Protein Analysis, Sickmann returned to the Ruhr region in 2008 when he accepted an appointment at his alma mater. At Ruhr University Bochum, he took on the professorship for Applied Proteomics and Bioanalytics, and at the same time he became Director of the Bioanalytics department at ISAS in Dortmund. A father of two children, one of the things he appreciates about Dortmund – in addition to networking in the Rhine-Ruhr scientific region – is his favourite “black and yellow” football club.

Since December 2025, Albert Sickmann has been one of five vice presidents who, together with the president, form the executive board of the Leibniz Association.

Select publications

Clinical and Experimental Medicine, Vol. 26, No. 1, 2026

Lang A, Pang TY, Piel S, Oehler D, Zweck E, Shahrjerdi K, Okkasian M, Georgy J, Reinders Y, Duplessis A, Tank J, Jordan J, Pfeiler S, Sickmann A,…

Oxygen-dependent modulation of the human complement system during acute normobaric hypoxia: a translational plasma proteomics study

https://doi.org/10.1007/s10238-026-02084-9

American Journal of Physiology - Heart and Circulatory Physiology, Vol. 330, No. 3, 2026, P. H854-H868

Eickelmann C, Gedik N, Lieder HR, Kollipara L, Sickmann A, Sturek M, Heusch G, Kleinbongard P.

Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs

https://doi.org/10.1152/ajpheart.00905.2025

BMC Medicine, Vol. 2025, No. 23, 2025

Sehgal R, Haacke N, Maguolo A, Solari FA, Jähnert M, Gottmann P, Nilsson E, Vaag A, Fischer-Posovszky P, Werberger A, Birkenfeld AL, Fritsche A,…

Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes

https://doi.org/10.1186/s12916-025-04560-7

Coral Reefs, 2025

Stuhr M, Kollipara L, Reymond CE, de Beer D, Ries J, Sickmann A, Westphal H.

Differing proteome responses to ocean acidification between two common pocilloporid corals

https://doi.org/10.1007/s00338-025-02801-y

PLOS Computational Biology, Vol. 21, No. 9, 2025, P. 1-25

Cheung HYF, Tantiwong C, Kale D, Gibbins JM, Watson SP, Heemskerk JWM, Sickmann A, Ahrends R, Dunster JL.

A computational framework for the investigation of phosphoinositide regulation

https://doi.org/10.1371/journal.pcbi.1013477

Proteomics. Clinical applications, Vol. 20, No. 1, 2025

Thilmany S, Thomas A, Reinders Y, Shakeri F, Vogel M, Sickmann A, Scholl C, Thevis M.

Hormonal Contraceptives and Depression: A Proteomic Analysis Using Neuronal Models

https://doi.org/10.1002/prca.70017

Cancer Discovery, Vol. 15, No. 12, 2025, P. 2437-2449

Yeh H, DelGaudio NL, Uygur B, Millet A, Khan A, Unlu G, Xiao M, Timson RC, Li C, Ozcan K, Smith KW, Nascentes Melo LM, Allies G, Basturk O, Sickmann…

Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling

https://doi.org/10.1158/2159-8290.CD-24-1556