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Portrait von Prof. Dr. Albert Sickmann

Albert Sickmann is the Chair of ISAS’s Board of Directors and Head of the Bioanalytics department and the Proteomics research group. His research focuses on providing quantitative evidence for post-translational modifications (protein phosphorylations, degradations, etc.), protein mutations and the detection of protein networks. To be precise, the trained biochemist and his team work on analysing the activation and inhibition of thrombocytes. In addition, they develop and optimise analytical methods relating to proteome research for use in precision medicine.

Sickmann’s interest in proteomics began to emerge right from the start of his scientific career: his PhD thesis, which he wrote at Ruhr University Bochum, was titled “Proteome Analysis of Human Cerebrospinal Fluid”. After holding various positions in Würzburg at the Rudolf Virchow Centre and as a Professor of Protein Analysis, Sickmann returned to the Ruhr region in 2008 when he accepted an appointment at his alma mater. At Ruhr University Bochum, he took on the professorship for Applied Proteomics and Bioanalytics, and at the same time he became Director of the Bioanalytics department at ISAS in Dortmund. A father of two children, one of the things he appreciates about Dortmund – in addition to networking in the Rhine-Ruhr scientific region – is his favourite “black and yellow” football club.

Since December 2025, Albert Sickmann has been one of five vice presidents who, together with the president, form the executive board of the Leibniz Association.

Select publications

Science, Vol. 393, No. 6818, 2026, P. eadw8520

Goswami S, Zhang Q, Yildiz AB, Das Adhikari U, Raghawan AK, Bulliard M, Sedhain S, Darawshi O, Celik CE, Cansiz F, Krempe CP, Rösler J, Allies G,…

Ceramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program

https://doi.org/10.1126/science.adw8520

Nature structural & molecular biology, Vol. 33, No. 8, 2026, P. 1252-1265

Vignane T, Hugo M, Hoffmann C, Reichert P, Katsouda A, D'Andrea D, Wang H, Tromm JV, Miler M, Comas F, Petrovic D, Chen S, Miljkovic JL, Stoychev D,…

Protein thiol alterations drive pathologic liquid-liquid phase separation in the aging brain

https://doi.org/10.1038/s41594-026-01857-w

Metabolism-Clinical and Experimental, Vol. 180, 2026, P. 156619

Godecke S, Heinen A, Appel T, Müller P, Stemmer T, Müller D, Flögel U, Herebian D, Solari FA, Deenen R, Köhrer K, Sickmann A, Godecke A.

Loss of cardiomyocyte AKT signaling causes deterioration of lipid metabolism and cellular atrophy

https://doi.org/10.1016/j.metabol.2026.156619

European Journal of Heart Failure, Vol. 28, No. Supplement_2, 2026

Lerchner T, Hau K, Paket U, Ahmadi S, Hawashin A, Ross S, Buehning F, Vogel J, Hentschel A, Klingel K, Akhyari P, Sickmann A, Rassaf T, Michel L.

Myocardial proteomics identify mitochondrial structural alterations in acute cardiac allograft rejection

https://doi.org/10.1093/ejhf/xuag193.679

Advanced Science, Vol. 13, No. 52, 2026, P. e76236

Jung M, Beer A, Ghosh S, Pylaeva E, Alshaar B, Tertel T, Leimkühler NB, Schroeder T, Gronewold J, Hagemann N, Mohamud Yusuf A, Frank B, Zhang Y,…

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

https://doi.org/10.1002/advs.76236

Proceedings of the National Academy of Sciences of the United States of America, Vol. 2026, No. 123 (24), 2026

Piao C, Dutkiewicz EP, Kollipara L, Sickmann A, Huang S, Sigrist SJ.

Active zone plasticity couples sleep need to presynaptic hypophosphorylation

https://doi.org/10.1073/pnas.2524065123

Clinical and Experimental Medicine, Vol. 26, No. 1, 2026

Lang A, Pang TY, Piel S, Oehler D, Zweck E, Shahrjerdi K, Okkasian M, Georgy J, Reinders Y, Duplessis A, Tank J, Jordan J, Pfeiler S, Sickmann A,…

Oxygen-dependent modulation of the human complement system during acute normobaric hypoxia: a translational plasma proteomics study

https://doi.org/10.1007/s10238-026-02084-9

American Journal of Physiology - Heart and Circulatory Physiology, Vol. 330, No. 3, 2026, P. H854-H868

Eickelmann C, Gedik N, Lieder HR, Kollipara L, Sickmann A, Sturek M, Heusch G, Kleinbongard P.

Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs

https://doi.org/10.1152/ajpheart.00905.2025

Proceedings of the National Academy of Sciences of the United States of America, Vol. 123, No. 2, 2026, P. e2521841122

Zhang Y, Silvestre-Roig C, Fu H, Alimohamadi H, Mandal T, Chen JW, Luo EW, Anda Jd, Linard Matos AL, Richter M, Mennella A, Lee H, Chan LC, Wang Y,…

SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting

https://doi.org/10.1073/pnas.2521841122

Proteomics. Clinical applications, Vol. 20, No. 1, 2025

Thilmany S, Thomas A, Reinders Y, Shakeri F, Vogel M, Sickmann A, Scholl C, Thevis M.

Hormonal Contraceptives and Depression: A Proteomic Analysis Using Neuronal Models

https://doi.org/10.1002/prca.70017