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Portrait von Prof. Dr. Albert Sickmann.

Albert Sickmann is the Chair of ISAS’s Board of Directors and Head of the Bioanalytics department and the Proteomics research group. His research focuses on providing quantitative evidence for post-translational modifications (protein phosphorylations, degradations, etc.), protein mutations and the detection of protein networks. To be precise, the trained biochemist and his team work on analysing the activation and inhibition of thrombocytes. In addition, they develop and optimise analytical methods relating to proteome research for use in precision medicine.

Sickmann’s interest in proteomics began to emerge right from the start of his scientific career: his PhD thesis, which he wrote at Ruhr University Bochum, was titled “Proteome Analysis of Human Cerebrospinal Fluid”. After holding various positions in Würzburg at the Rudolf Virchow Centre and as a Professor of Protein Analysis, Sickmann returned to the Ruhr region in 2008 when he accepted an appointment at his alma mater. At Ruhr University Bochum, he took on the professorship for Applied Proteomics and Bioanalytics, and at the same time he became Director of the Bioanalytics department at ISAS in Dortmund. A father of two children, one of the things he appreciates about Dortmund – in addition to networking in the Rhine-Ruhr scientific region – is his favourite “black and yellow” football club.

Select publications

Journal of Cellular and Molecular Medicine, Vol. 28, No. 8, 2024

Athamneh M, Daya N, Hentschel A, Gangfuss A, Ruck T, Marina AD, Schara-Schmidt U, Sickmann A, Güttsches A, Deschauer M, Preusse C, Vorgerd M, Roos A.

Proteomic studies in VWA1-related neuromyopathy allowed new pathophysiological insights and the definition of blood biomarkers

https://doi.org/10.1111/jcmm.18122

FASEB Journal, Vol. 38, No. 4, 2024, P. e23468

Provenzale I, Solari FA, Schönichen C, Brouns SLN, Fernández DI, Kuijpers MJE, van der Meijden PEJ, Gibbins JM, Sickmann A, Jones C, Heemskerk JWM.

Endothelium-mediated regulation of platelet activation: Involvement of multiple protein kinases

https://doi.org/10.1096/fj.202300360RR

Clinical Proteomics, Vol. 21, No. 1, 2024, P. 12

Hentschel A, Piontek G, Dahlmann R, Findeisen P, Sakson R, Carbow P, Renné T, Reinders Y, Sickmann A.

Highly sensitive therapeutic drug monitoring of infliximab in serum by targeted mass spectrometry in comparison to ELISA data

https://doi.org/10.1186/s12014-024-09464-x

Journal of Chromatography A, Vol. 1717, 2024, P. 464691

Kasarla SS, Flocke V, Saw NMT, Fecke A, Sickmann A, Gunzer M, Flögel U, Phapale P.

In-vivo tracking of deuterium metabolism in mouse organs using LC-MS/MS

https://doi.org/10.1016/j.chroma.2024.464691

Acta Neuropathologica, Vol. 147, No. 1, 2024, P. 12

Kleefeld F, Horvath R, Pinal-Fernandez I, Mammen AL, Casal-Dominguez M, Hathazi D, Melchert S, Hahn K, Sickmann A, Muselmann-Genschow C, Hentschel A,…

Multi-level profiling unravels mitochondrial dysfunction in myotonic dystrophy type 2

https://doi.org/10.1007/s00401-023-02673-y

Communications Biology, Vol. 7, No. 1, 2024, P. 12

Michaud SA, Pětrošová H, Sinclair NJ, Kinnear AL, Jackson AM, McGuire JC, Hardie DB, Bhowmick P, Ganguly M, Flenniken AM, Nutter LMJ, McKerlie C,…

Multiple reaction monitoring assays for large-scale quantitation of proteins from 20 mouse organs and tissues

https://doi.org/10.1038/s42003-023-05687-0

Nature Communications, Vol. 14, 2023, P. 1-13

Cibir Z, Hassel J, Sonneck J, Kowitz L, Beer A, Kraus A, Hallekamp G, Rosenkranz M, Raffelberg P, Olfen S, Smilowski K, Burkard R, Helfrich I, Tuz…

ComplexEye:a multi-lens array microscope for high-throughput embedded immune cell migration analysis

https://doi.org/10.1038/s41467-023-43765-3

bio-protocol, Vol. 13, No. 22, 2023, P. e4880

Kale D, Sachsenheimer T, Sickmann A, Brügger B.

A New, Rapid Method for the Quantification of Dolichyl Phosphates in Cell Cultures Using TMSD Methylation Combined with LC-MS Analysis

https://doi.org/10.21769/BioProtoc.4880

Biomedicines, Vol. 11, No. 10, 2023

Wang C, Stöckl S, Pattappa G, Schulz D, Hofmann K, Ilic J, Reinders Y, Bauer RJ, Sickmann A, Grässel S.

Extracellular Vesicles Derived from Osteogenic-Differentiated Human Bone Marrow-Derived Mesenchymal Cells Rescue Osteogenic Ability of Bone Marrow-Derived Mesenchymal Cells Impaired by Hypoxia

https://doi.org/10.3390/biomedicines11102804