Dielectric barrier electrospray ionisation method for liquid samples and subsequent mass-spectrometry analysis of the created sample ion
Elektrospray ionisation without direct contact to the live electrode thanks to dielectric barrier against charge transfer
No electrode erosion
Combination of electrospray ionisation with free-flow electrophoresis possible
Approach:
The process permits the operation of several dielectric barrier electrosprays at the outlets of a (miniaturized) FFE or of several parallel separation systems. The interface is meanwhile connected to the outputs of the FFE chip. The analytes sprayed from several ducts can be measured mass-spectrometrically and averaged over several cycles.
Applications:
The process is helpful wherever analyte separation in an aqueous system is to be combined with mass-spectrometric detection, e.g. in the parallel connection of several separation systems with one and the same mass spectrometer.
Patent status:
German patent granted; DE (ref.: 10 2011 015 517.1), applications: EP (ref.: 12 717 215.3-1803), JP (ref.: 2014-501558)
References:
Schilling, M.; Janasek, D. and Franzke, J.; Electrospray-ionisation driven by dielectric polarization. Anal. Bioanal. Chem., 391(2):555–561, 2008.
Stark, A.-K.; Schilling, M.; Janasek, D. and Franzke, J.; Characterization of dielectric barrier electrospray ionization for mass spectrometric detection. Anal. Bioanal. Chem. 397(5): 1767–1772, 2010.
Reginskaya, I.; Schilling, M.; Adali, G.; Jestel, G.; Janasek, D. and Franzke, J.; Emitter-assigned multi-dielectric barrier-nano-electrospray ionization mass spectrometry. Anal. Bioanal. Chem. 407(21):6537–6542, 2015.