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Advancing Analytics

We develop and combine technologies into four-dimensional analytical methods for health research. Our goal: With our analytics for precision medicine, we want to contribute to optimising the prevention, diagnosis and therapy of various diseases.

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Research Programmes

In our three programmes, we conduct research on various interdisciplinary projects. In one of our research programmes, for example, we combine analytical procedures and develop multi-method concepts in order to elucidate disease mechanisms and identify potential therapeutic approaches - always with a clear application purpose for the following preclinical research.

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ISAS Kompakt

13th March 2024

Cirrhosis of the Liver: Migrating Immune Cells Act as an Early Warning System

The life expectancy of patients with liver cirrhosis depends crucially on the occurrence of disease-associated complications, such as infections. Until now, however, an ability to predict these at an early stage has been lacking. A problem, often hindering doctors from administering antibiotics or even performing a liver transplant in time. Researchers at ISAS led by Prof Dr Matthias Gunzer therefore investigated the question: Could the mobility of certain immune cells be the decisive indicator of an impending deterioration in health?

27th February 2024

3 Questions for… Dr Christopher Nelke

As a participant in the Clinician Scientist programme and physician at the Clinic for Neurology at Düsseldorf University Hospital (Universitätsklinikum Düsseldorf, UKD), Dr Christopher Nelke researches neuromuscular diseases. In this interview, he talks about his two-week guest stay at ISAS and the challenges that arise between the hospital bed and research.

Das Bild zeigt Dr. Christopher Nelke im Labor. In den Händen hält er eine Probe. The picture shows Dr Christopher Nelke in the laboratory. He is holding a sample in his hands.
20th February 2024

SARS-CoV-2: The Very Latest Methods Clarify the Active Agents and the Mechanism of Action of Ancient Self-Medications

Prophylactic, soothing or even healing agents, mostly natural substances, have been known to natural medicine since ancient times. But what about viral infections? Could infusions made from sage or perilla also be used against SARS-CoV-2 infections -as a prevention or an aid to healing? An interdisciplinary team of researchers led by Prof Dr Mirko Trilling from the Faculty of Medicine at the University of Duisburg-Essen (UDE) and scientists at ISAS investigated these questions during the coronavirus pandemic.

Das Bild zeigt Prof. Dr. Mirko Trilling mit verschränkten Armen, an einer Wand lehnend. The picture shows Prof Dr Mirko Trilling with his arms folded, leaning against a wall.
7th February 2024

A Long Sought-After Combination Method in Mass Spectrometry

Researchers who analyse complex samples using mass spectrometers are often faced with the challenge that the substances they contain are fundamentally different. Some are chemically polar, others are non-polar. Until now, this has required two complex separate analyses. But a researcher at ISAS has developed a method with which even less polar substances can be included in a standard mass spectrometric analysis for polar biological substances.

Daniel Foest steht im Labor und hält ein Papier mit einer Leberprobe, die er am Massenspektrometer untersucht.
12th January 2024

“My research is literally hard work"

Darleen Hüser is looking for the immuno-cellular fingerprint of rheumatoid arthritis. In this interview, the doctoral student reveals her razor-sharp research and why she needs different microscopes.

Das Porträt zeigt ISAS-Doktorandin Darleen Hüser aus der Arbeitsgruppe Bioimaging.
21st December 2023

Science Slam: Humorous Science Communication Is Fun for Everyone

Talking lab equipment, artificial intelligence and expertise from the North Pole - this colourful mix of topics characterised the latest Science Slam at the institute. Four ISAS employees demonstrated with their specialist knowledge and plenty of humour how science communication can be fun for everyone involved.

Luisa Becher fotografiert die vier Teilnehmenden des ISAS Science Slam.
20th December 2023

The Art of Balancing: Accuracy in Image Analysis

What challenges in analysing microscopic images can be mastered with artificial intelligence if the latter is incorporated at an early stage? Why should researchers think about the target metrics of image analysis when planning their experiment? Dr Jianxu Chen has now put together his tips, recently published in the journal Nature Methods, as a kind of checklist for researchers.

Die Abbildung zeigt eine Wage und symbolisiert das Gleichgewicht zwischen Analyse und Genauigkeit bei der Validierung von biomedizinischen Aufnahmen.
1st December 2023

Bone research: ISAS participates in the new "DIONE" Collaborative Research Centre

The nationwide project recently funded by the German Research Foundation is focussing on inflammation-induced bone loss. Researchers from Dortmund, Dresden, Erlangen/Nuremberg and Ulm want to find out exactly how inflammatory diseases - such as rheumatoid arthritis or intestinal diseases - damage bones. Among other things, their research aims to help identify new therapies for skeletal-associated diseases.

Bone structur with osteoporosis.
4th May 2023

What are you doing at ISAS, Joy?

What role does the oxygen levelin the blood play in thrombosis? Joy Amrei Brummel is tackling this and other questions in her bachelor's thesis. The 24-year-old student reports on how she applies her university knowledge in the ISAS laboratory.

Joy Amrei Brummel stellt eine Probe in die Zentrifuge.
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Publications

Clinical Proteomics, Vol. 21, No. 1, 2024, P. 12

Hentschel A, Piontek G, Dahlmann R, Findeisen P, Sakson R, Carbow P, Renné T, Reinders Y, Sickmann A.

Highly sensitive therapeutic drug monitoring of infliximab in serum by targeted mass spectrometry in comparison to ELISA data

https://doi.org/10.1186/s12014-024-09464-x

Journal of Chromatography A, Vol. 1717, 2024, P. 464691

Kasarla SS, Flocke V, Saw NMT, Fecke A, Sickmann A, Gunzer M, Flögel U, Phapale P.

In-vivo tracking of deuterium metabolism in mouse organs using LC-MS/MS

https://doi.org/10.1016/j.chroma.2024.464691

Molecular Metabolism, Vol. 79, 2023, P. 101859

Janz A, Walz K, Cirnu A, Surjanto J, Urlaub D, Leskien M, Kohlhaas M, Nickel A, Brand T, Nose N, Wörsdörfer P, Wagner N, Higuchi T, Maack C, Dudek J,…

Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes

https://doi.org/10.1016/j.molmet.2023.101859

Chemistry-A European Journal, Vol. 30, No. 11, 2023, P. e202303506

Sink A, Gerwe H, Hübner H, Boivin-Jahns V, Fender J, Lorenz K, Gmeiner P, Decker M.

"Photo-Adrenalines": ß2-Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling

https://doi.org/10.1002/chem.202303506

Nature Methods, 2024

Zhou Y, Cao J, Sonneck J, Banerjee S, Dörr S, Grüneboom A, Lorenz K, Zhang S, Chen J.

EfficientBioAI: making bioimaging AI models efficient in energy and latency

https://doi.org/10.1038/s41592-024-02167-z

Elsevier, Vol. 2024, 2024, P. 59-65

Hinrichs K, Kratz C, Furchner A.

Hyperspectral and Time-Resolved IR Laser Polarimetry

https://doi.org/10.1016/B978-0-323-85669-0.00001-5

Elsevier, 2024, P. 360-367

Hinrichs K, Furchner A, Rappich J, Kratz C.

Optofluidic analysis of monolayers with infrared microscopy

https://doi.org/10.1016/B978-0-323-85669-0.00002-7

Elsevier, Vol. 2024, 2024, P. 514-520

Hinrichs K, Sun G, Rappich J, Furchner A.

Structure and chemical analysis in thin films by in situ IR ellipsometry

https://doi.org/10.1016/B978-0-323-85669-0.00019-2

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