Dielectric barrier electrospray ionisation method for liquid samples and subsequent mass-spectrometry analysis of the created sample ion

  • Elektrospray ionisation without direct contact to the live electrode thanks to dielectric barrier against charge transfer
  • No electrode erosion
  • Combination of electrospray ionisation with free-flow electrophoresis possible

The process permits the operation of several dielectric barrier electrosprays at the outlets of a (miniaturized) FFE or of several parallel separation systems. The interface is meanwhile connected to the outputs of the FFE chip. The analytes sprayed from several ducts can be measured mass-spectrometrically and averaged over several cycles.

The process is helpful wherever analyte separation in an aqueous system is to be combined with mass-spectrometric detection, e.g. in the parallel connection of several separation systems with one and the same mass spectrometer.

Patent status:
German patent granted; DE (ref.: 10 2011 015 517.1), applications: EP (ref.: 12 717 215.3-1803), JP (ref.: 2014-501558)

Schilling, M.; Janasek, D. and Franzke, J.; Electrospray-ionisation driven by dielectric polarization. Anal. Bioanal. Chem., 391(2):555–561, 2008.

Stark, A.-K.; Schilling, M.; Janasek, D. and Franzke, J.; Characterization of dielectric barrier electrospray ionization for mass spectrometric detection. Anal. Bioanal. Chem. 397(5): 1767–1772, 2010.

Reginskaya, I.; Schilling, M.; Adali, G.; Jestel, G.; Janasek, D. and Franzke, J.; Emitter-assigned multi-dielectric barrier-nano-electrospray ionization mass spectrometry. Anal. Bioanal. Chem. 407(21):6537–6542, 2015.

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