The research group aims to detect the molecular and cellular processes that underlie so-called immuno-vascular interactions under inflammatory conditions. In order to understand, for example, an infection and its corresponding immune response, the scientists look at the process from different angles.

One of the imaging techniques that the researchers use is fluorescence microscopy. This form of light microscopy includes, among others, light sheet fluorescence microscopy (LSFM). LSFM enables the scientists to determine information on different classes of molecules and their spatial distribution patterns at the same time. In addition to imaging techniques like LSFM, the researchers also work with confocal laser scanning microscopy (CLSM) and two-photon laser scanning microscopy (TPLSM). They enable a three-dimensional analysis of biological samples from a cellular to sub-cellular level.

The researchers conduct studies on animal and human samples, take measurements of intact organs and integrate artificial intelligence into their image analyses.

Current Publications

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function

Molecular Neurobiology,
Type: Journal article

Calibration by differentiation - Self-supervised calibration for X-ray microscopy using a differentiable cone-beam reconstruction operator

Journal of Microscopy, Vol. 287, Nr. 2, , P. 81–92
Type: Journal article

NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice

Brain, Vol. 145, Nr. 11, , P. 3999–4015
Type: Journal article

Imaging innate immunity

Immunological Reviews, Vol. 306, Nr. 1, , P. 293–303
Type: Journal article

A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo Metastatic Melanoma Models

Advanced Functional Materials, Vol. 32, Nr. 2,
Type: Journal article

Phenotypical and Myopathological Consequences of Compound Heterozygous Missense and Nonsense Variants in SLC18A3

Cells, Vol. 10, Nr. 12,
Type: Journal article