Bioimaging

The research group aims to detect the molecular and cellular processes that underlie so-called immuno-vascular interactions under inflammatory conditions. In order to understand, for example, an infection and its corresponding immune response, the scientists look at the process from different angles.

One of the imaging techniques that the researchers use is fluorescence microscopy. This form of light microscopy includes, among others, light sheet fluorescence microscopy (LSFM). LSFM enables the scientists to determine information on different classes of molecules and their spatial distribution patterns at the same time. In addition to imaging techniques like LSFM, the researchers also work with confocal laser scanning microscopy (CLSM) and two-photon laser scanning microscopy (TPLSM). They enable a three-dimensional analysis of biological samples from a cellular to sub-cellular level.

The researchers conduct studies on animal and human samples, take measurements of intact organs and integrate artificial intelligence into their image analyses.

To ensure bone homeostasis, the bone surface – the periosteum – and the cortical bone are supplied by different types of blood vessels, such as fine capillaries (red) and large arteries (green and red). ©ISAS / Anika Grüneboom

Current Publications

Hentschel A, Meyer N, Kohlschmidt N, Groß C, Sickmann A, Schara-Schmidt U, Förster F, Töpf A, Christiansen J, Horvath R, Vorgerd M, Thompson R, Polaparapu K, Lochmüller H, Preusse C, Hannappel L, Schänzer A, Grüneboom A, Gangfuß A, Roos A.

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function

Molecular Neurobiology, 2023

Type: Journal article

DOI: /doi.org/10.1007/s12035-023-03219-9

Thies M, Wagner F, Huang Y, Gu M, Kling L, Pechmann S, Aust O, Grüneboom A, Schett G, Christiansen S, Maier A.

Calibration by differentiation - Self-supervised calibration for X-ray microscopy using a differentiable cone-beam reconstruction operator

Journal of Microscopy, Vol. 287, Nr. 2, 2022, P. 81–92

Type: Journal article

DOI: /doi.org/10.1111/jmi.13125

Jennings MJ, Kagiava A, Vendredy L, Spaulding EL, Stavrou M, Hathazi D, Grüneboom A, De Winter V, Gess B, Schara U, Pogoryelova O, Lochmüller H, Borchers CH, Roos A, Burgess RW, Timmerman V, Kleopa KA, Horvath R.

NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice

Brain, Vol. 145, Nr. 11, 2022, P. 3999–4015

Type: Journal article

DOI: /doi.org/10.1093/brain/awac055

Grüneboom A, Aust O, Cibir Z, Weber F, Hermann DM, Gunzer M.

Imaging innate immunity

Immunological Reviews, Vol. 306, Nr. 1, 2022, P. 293–303

Type: Journal article

DOI: /doi.org/10.1111/imr.13048

Schmid R, Schmidt SK, Detsch R, Horder H, Blunk T, Schrufer S, Schubert DW, Fischer L, Thievessen I, Heltmann-Meyer S, Steiner D, Schneidereit D, Friedrich O, Grüneboom A, Amouei H, Wajant H, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A.

A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo Metastatic Melanoma Models

Advanced Functional Materials, Vol. 32, Nr. 2, 2022

Type: Journal article

DOI: /doi.org/10.1002/adfm.202107993

Della Marina A, Arlt A, Schara-Schmidt U, Depienne C, Gangfuß A, Koelbel H, Sickmann A, Freier E, Kohlschmidt N, Hentschel A, Weis J, Czech AA, Grüneboom A, Roos A.

Phenotypical and Myopathological Consequences of Compound Heterozygous Missense and Nonsense Variants in SLC18A3

Cells, Vol. 10, Nr. 12, 2021

Type: Journal article

DOI: /doi.org/10.3390/cells10123481