Analytics and Microfluidics for Drug Development

The Leibniz Research Cluster (LRC) for "Bio/synthetic multifunctional micro production units – novel ways in drug development" aims to develop analytical strategies and methods that enable the investigation of metabolites in cell-free, technical compartments. In the scope of the LRC, ISAS has established the CARS Microscopy group, which uses optical technologies to characterise the substances and reactions investigated by the LRC partners and develops a micropreparative purification method with integrated in situ analytics.

In their main project, the group uses and optimises different methods such as mass spectrometry, Raman scattering and coherent anti-Stokes Raman scattering (CARS), aiming to identify the composition of even the smallest sample quantities. To this end, the methods are coupled with microfluidic setups. Already, the group was able to realise a parallel CARS and MS analysis of samples separated by HPLC, thus combining two different analytical approaches in one measurement.

However, the project focuses not only on measurements in these miniaturised systems, but also on developing microfluidic separation and purification methods to extract desired and undesired reaction products from the process and to return unconverted starting materials to the reactor. The project is proportionately funded by the Federal Ministry of Education and Research (BMBF).