Innovative analytics
for health research

New findings about the composition, structure and dynamics of new materials and biological systems can only be obtained by developing innovative analytical (measuring) processes. The knowledge gained in this manner is crucial for deepening our understanding of the causes of disease on a molecular level, paves the way to more precise, personalized medical treatments, and is a key to the characterization and development of new, treatment-improving materials; it calls for and is subject to a constant process of optimization.

The scientific work at ISAS concerns the development of new methods on all levels – from basic research through to the production of prototypes. The following pages will provide you with detailed information about our research topics and projects.

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Research programmes

Disease Mechanisms and Targets

Disease Mechanisms and Targets

The projects in the Disease Mechanisms and Targets programme focus on a central aspect of health research: the investigation of molecular mechanisms that are involved in pathogenesis.

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Biomarkers

Biomarkers

The projects in the Biomarkers programme focus on the identification and validation of biomarkers as well as on the improved detection of such molecules in a complex biological matrix.

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Imaging

Imaging

ISAS uses its long-standing experience in optical spectroscopy to develop its methods towards imaging applications for health research. In the Imaging programme, methods such as Raman spectroscopy, high-resolution fluorescence, or CARS microscopy are combined to develop novel analytical platforms.

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Biointerfaces

Biointerfaces

The projects in this programme focus on non-destructive and non-invasive analytical methods for minute samples of biomolecules on solid-liquid surfaces. Such biohybrid interfaces are especially suited for sensors or for studying biomolecular interactions, cell templates, and biomolecule binding to surfaces.

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ISAS Strategy Fund

ISAS Strategy Fund

The objective of the Strategy Fund “Competition” is to promote scientific ideas that particularly support the strategic aims of ISAS. For this internal competition, the institute has established the funding lines “Integrative Research” and “Early Independence”, which are advertised alternately.

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Recent publications

Tagged benzoxazin-4-ones as novel activity-based probes for serine proteases

ChemBioChem,
Type: Journal article
DOI: /doi.org/10.1002/cbic.202000848

Molecular pathophysiology of human MICU1-deficiency

Neuropathology and applied neurobiology,
Type: Journal article
DOI: /doi.org/10.1111/nan.12694

Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration

Journal of Experimental Medicine, Vol. 218, Nr. 1,
Type: Journal article
DOI: /doi.org/10.1084/jem.20192378

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications

Journal of Biological Chemistry, Vol. 295, Nr. 52, , P. 18213–18225
Type: Journal article
DOI: /doi.org/10.1074/jbc.RA120.015882

Bioorthogonal Reactions in Activity-Based Protein Profiling

Molecules, Vol. 25, Nr. 24,
Type: Journal article
DOI: /doi.org/10.3390/molecules25245994

Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor

ACS Chemical Biology, Vol. 15, Nr. 12, , P. 3106–3111
Type: Journal article
DOI: /doi.org/10.1021/acschembio.0c00802

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