New findings about the composition, structure and dynamics of new materials and biological systems can only be obtained by developing innovative analytical (measuring) processes. The knowledge gained in this manner is crucial for deepening our understanding of the causes of disease on a molecular level, paves the way to more precise, personalized medical treatments, and is a key to the characterization and development of new, treatment-improving materials; it calls for and is subject to a constant process of optimization.

The scientific work at ISAS concerns the development of new methods on all levels – from basic research through to the production of prototypes. The following pages will provide you with detailed information about our research topics and projects.

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Research programmes

Disease Mechanisms and Targets

Disease Mechanisms and Targets

Biomarkers

Biomarkers

Imaging

Imaging

Biointerfaces

Biointerfaces

ISAS Strategy Fund

ISAS Strategy Fund

Recent publications

Tagged benzoxazin-4-ones as novel activity-based probes for serine proteases

ChemBioChem,
Type: Journal article

Molecular pathophysiology of human MICU1-deficiency

Neuropathology and applied neurobiology,
Type: Journal article

Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration

Journal of Experimental Medicine, Vol. 218, Nr. 1,
Type: Journal article

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications

Journal of Biological Chemistry, Vol. 295, Nr. 52, , P. 18213–18225
Type: Journal article

Bioorthogonal Reactions in Activity-Based Protein Profiling

Molecules, Vol. 25, Nr. 24,
Type: Journal article

Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor

ACS Chemical Biology, Vol. 15, Nr. 12, , P. 3106–3111
Type: Journal article

More publications