Innovative analytics
for health research

New findings about the composition, structure and dynamics of new materials and biological systems can only be obtained by developing innovative analytical (measuring) processes. The knowledge gained in this manner is crucial for deepening our understanding of the causes of disease on a molecular level, paves the way to more precise, personalized medical treatments, and is a key to the characterization and development of new, treatment-improving materials; it calls for and is subject to a constant process of optimization.

The scientific work at ISAS concerns the development of new methods on all levels – from basic research through to the production of prototypes. The following pages will provide you with detailed information about our research topics and projects.

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Research programmes

Disease Mechanisms and Targets

Disease Mechanisms and Targets

The projects in the Disease Mechanisms and Targets programme focus on a central aspect of health research: the investigation of molecular mechanisms that are involved in pathogenesis.

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Biomarkers

Biomarkers

The projects in the Biomarkers programme focus on the identification and validation of biomarkers as well as on the improved detection of such molecules in a complex biological matrix.

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Biointerfaces

Biointerfaces

The projects in this programme focus on non-destructive and non-invasive analytical methods for minute samples of biomolecules on solid-liquid surfaces. Such biohybrid interfaces are especially suited for sensors or for studying biomolecular interactions, cell templates, and biomolecule binding to surfaces.

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Imaging

Imaging

ISAS uses its long-standing experience in optical spectroscopy to develop its methods towards imaging applications for health research. In the Imaging programme, methods such as Raman spectroscopy, high-resolution fluorescence, or CARS microscopy are combined to develop novel analytical platforms.

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ISAS Strategy Fund

ISAS Strategy Fund

The objective of the Strategy Fund “Competition” is to promote scientific ideas that particularly support the strategic aims of ISAS. For this internal competition, the institute has established the funding lines “Integrative Research” and “Early Independence”, which are advertised alternately.

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Recent publications

Hydride generation atomic absorption spectrometry with a dielectric barrier discharge atomizer: Method optimization and evaluation of analytical performance for tin

Spectrochimica Acta Part B-Atomic Spectroscopy, Vol. 2019, Nr. 158,
Type: Journal article
DOI: /doi.org/10.1016/j.sab.2019.05.019

Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner

Scientific reports, Vol. 9, Nr. 1,
Type: Journal article
DOI: /doi.org/10.1038/s41598-019-47184-7

Vac8 Controls Vacuolar Membrane Dynamics during Different Autophagy Pathways in Saccharomyces cerevisiae

Cells, Vol. 2019, Nr. 7,
Type: Journal article
DOI: /doi.org/10.3390/cells8070661

Enhancement of emission from indium in flowing liquid anode atmospheric pressure glow discharge using organic media

Talanta, Vol. 2019, Nr. 204, , P. 304–309
Type: Journal article
DOI: /doi.org/10.1016/j.talanta.2019.06.015

Biofouling-Resistant Porous Membranes with a Precisely Adjustable Pore Diameter via 3D Polymer Grafting

ACS Applied Materials & Interfaces, Vol. 11, Nr. 20, , P. 18268–18275
Type: Journal article
DOI: /doi.org/10.1021/acsami.9b06679

Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique

Nature Communications, Vol. 2019, Nr. 10(1), , P. 1–12
Type: Journal article
DOI: /doi.org/10.1038/s41467-019-10182-4

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