Biospectroscopy

In the Biospectroscopy Research Department, we set ourselves the goal of improving early detection of diseases, especially of the cardiovascular system and for tumors. Our aim is to improve the assessment of individual risks in existing diagnoses with the help of modern imaging techniques. Starting from experimental model systems, we first investigate the complex biochemical and cellular basis of diseases in different phases of their development and then transfer the results to the human body.
State-of-the-art imaging techniques play an important role in this procedure. We use different methods of mesoscopic and high-resolution 3-D microscopy to visualize cellular and biophysical processes in intact tissue and whole organs. These results are combined with innovative analytical methods developed at ISAS in order to make all relevant biomolecule classes measurable without markers.

The result is a comprehensive description of the state of complex biological systems under physiological and pathological conditions.
With such a combination of modern imaging and molecular analysis, we are able to capture all orders of magnitude from molecules to supracellular structures required for spatially and temporally resolved analysis. The findings on biological systems gained from this holistic approach will then help to develop new tailor-made prevention and therapy measures.

The department was established in August 2019 and is currently being built.

 

Current Publications

CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection

Science immunology, Vol. 7, Nr. 68, , P. eabi9126
Type: Journal article

Post-ischemic protein restriction induces sustained neuroprotection, neurological recovery, brain remodeling, and gut microbiota rebalancing

Brain behavior and immunity, Vol. 100, , P. 134–144
Type: Journal article

Roles of Polymorphonuclear Neutrophils in Ischemic Brain Injury and Post-Ischemic Brain Remodeling

Frontiers in Immunology, Vol. 12, , P. 825572
Type: Journal article

High-resolution three-dimensional imaging for precise staging in melanoma

European Journal of Cancer, Vol. 159, , P. 182–193
Type: Journal article

Molecular pathophysiology of human MICU1-deficiency

Neuropathology and applied neurobiology, Vol. 47, Nr. 6, , P. 840–855
Type: Journal article

Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy

European heart journal, Vol. ehab430,
Type: Journal article