In the case of sterile inflammations, such as a stroke or myocardial infarction, massive inflammatory responses are triggered in the body even without direct external action. In order to achieve a better understanding of immune responses to sterile infections in different organ systems, the Biofluorescence research group focuses on identifying the cellular and molecular immune mechanisms underlying their development.

One focus is on the detailed molecular analysis of specific tissue niches encountered by invading immune cells in inflamed organs or in tumors. These are fundamentally different from the environment in, for example, bone marrow, blood or lymphoid organs - the sites where immune cells reside under non-inflammatory conditions. Immune cells respond rapidly and with fundamental changes in their molecular functionality to changes in their environment. These molecular transformations dramatically alter immune cell responses to common stimuli, but are still not fully understood.

To better understand the role of the immune response in sterile inflammation, the researchers induce various disease states in animal models. They then analyse the inflamed tissues and infiltrated immune cells using advanced light and electron microscopy. The tissues are then further molecularly characterized using flow cytometry, mass spectrometry (MS) and MS-based imaging. In translational studies, the scientists investigate the response of human immune cells to similar triggers in vitro. In various collaborations with partners from the University Hospital Essen, the researchers at ISAS also analyse cells from human patients. With the results obtained, they hope to identify potential new therapeutic targets, subsequently verify them experimentally, and ultimately derive new therapy regimens for patients from the results.


Current Publications

A20 and the non-canonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny

JCI insight, Vol. 8, Nr. 4,
Type: Journal article

Identification of herbal teas and their compounds eliciting antiviral activity against SARS-CoV-2 in vitro

BMC biology, Vol. 20, Nr. 1, , P. 264
Type: Journal article

Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recovery

Frontiers in Immunology, Vol. 13, , P. 1037330
Type: Journal article

The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury

Nature Communications, Vol. 13, Nr. 1, , P. 5786
Type: Journal article

Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions

The Journal of allergy and clinical immunology, Vol. 150, Nr. 4, , P. 909–919.e8
Type: Journal article

Antibody-guided Molecular Imaging of Aspergillus Lung Infections in Leukemia Patients

Journal of nuclear medicine, Vol. 63, Nr. 9, , P. 1450–1451
Type: Journal article