The Proteomics group aims at describing and understanding biological systems at different levels of complexity. To this end, it develops methods to qualitatively and quantitatively detect biomolecules, particularly proteins.

The group is concerned both with the structure of proteins and with the dynamic changes triggered by external influences, metabolic processes and communication processes in cells. These play a role in almost all diseases – including common illnesses, such as cardiovascular diseases, cancer and diabetes. The potential applications for this work therefore extend from purely basic research through to new developments for medical diagnostics. An important aspect in this context is a targeted, personalised treatment of illnesses. However, such a therapy approach is not possible until it is known precisely where and how which (bio-)molecule acts inside the cell, how it is transported and where it binds; in other words, how the biological system works as a whole.

Current Publications

Multi-omics approaches to study platelet mechanisms

Current Opinion in Chemical Biology, Vol. 73, , P. 102253
Type: Journal article

Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells

Chemical Science, Vol. 14, Nr. 7, , P. 1666–1672
Type: Journal article

Quantification of Dolichyl Phosphates Using Phosphate Methylation and Reverse-Phase Liquid Chromatography–High Resolution Mass Spectrometry

Analytical Chemistry, Vol. 95, Nr. 6, , P. 3210–3217
Type: Journal article

Molecular mechanisms in chloroquine-exposed muscle cells elucidated by combined proteomic and microscopic studies

Neuropathology and Applied Neurobiology, Vol. 49, Nr. 1,
Type: Journal article

Novel Green Fluorescent Polyamines to Analyze ATP13A2 and ATP13A3 Activity in the Mammalian Polyamine Transport System

Biomolecules, Vol. 13, Nr. 2,
Type: Journal article

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function

Molecular Neurobiology,
Type: Journal article