The projects in the Disease Mechanisms and Targets programme focus on a central aspect of health research: the investigation of molecular mechanisms that are involved in pathogenesis. This work is mandatory for developing successful treatments, as novel diagnosis and therapy concepts require the identification of potential target molecules.
A multimethod approach is our way to gain a detailed understanding of molecular disease processes. This approach integrates proteomics, lipidomics, and metabolomics data to gain a comprehensive view of pathomechanisms. The resulting multiomics techniques are combined with biochemical, physiological, biospectroscopy, and imaging approaches (in close collaboration with the Biomarkers, Biointerfaces, and Imaging programmes). One important topic in this programme are cardiovascular diseases and their pathomechanisms, from heart failure to platelet dysfunction.