To understand and elucidate the molecular basis of diseases is only the first step towards improved diagnosis and therapy concepts. Another important challenge in this context is to find dependable markers that can be used for the reliable identification and discrimination of different diseases. Given the enormous number of potential analytes in biological systems, it is furthermore necessary to employ methods for high precision measurements in biomarker research.
Therefore, projects in the Biomarkers programme focus on the identification and validation of biomarkers – i. e. signatures that can be used as indicators for defined processes – as well as on the improved detection of such molecules in a complex biological matrix. The results of this research are complemented by corresponding techniques developed in the Biointerfaces and Imaging programmes to identify validated biomarkers in minute sample volumes and in point-of-care situations.