New findings about the composition, structure and dynamics of new materials and biological systems can only be obtained by developing innovative analytical (measuring) processes. The knowledge gained in this manner is crucial for deepening our understanding of the causes of disease on a molecular level, paves the way to more precise, personalized medical treatments, and is a key to the characterization and development of new, treatment-improving materials; it calls for and is subject to a constant process of optimization.
The scientific work at ISAS concerns the development of new methods on all levels – from basic research through to the production of prototypes. The following pages will provide you with detailed information about our research topics and projects.
Research programmes
Disease Mechanisms and Targets
The projects in the Disease Mechanisms and Targets programme focus on a central aspect of health research: the investigation of molecular mechanisms that are involved in pathogenesis.
The projects in the Biomarkers programme focus on the identification and validation of biomarkers as well as on the improved detection of such molecules in a complex biological matrix.
ISAS uses its long-standing experience in optical spectroscopy to develop its methods towards imaging applications for health research. In the Imaging programme, methods such as Raman spectroscopy, high-resolution fluorescence, or CARS microscopy are combined to develop novel analytical platforms.
The objective of the Strategy Fund “Competition” is to promote scientific ideas that particularly support the strategic aims of ISAS. For this internal competition, the institute has established the funding lines “Integrative Research” and “Early Independence”, which are advertised alternately.
Gangfuß A,
Hentschel A,
Rademacher N,
Sickmann A,
Stüve B,
Horvath R,
Claudia G,
Kohlschmidt N,
Förster F,
Abicht A,
Schänzer A,
Schara-Schmidt U,
Roos A,
Della Marina A.
Identification of a novel homozygous SCO2 variant in siblings with early-onset axonal Charcot-Marie-Tooth disease
Loroch S,
Kopczynski D,
Schneider AC,
Schumbrutzki C,
Feldmann I,
Panagiotidis E,
Reinders Y,
Sakson R,
Solari F,
Vening A,
Swieringa F,
Heemskerk JWM,
Grandoch M,
Dandekar T,
Sickmann A.
Toward Zero Variance in Proteomics Sample Preparation
Journal of Proteome Research, Vol. 21, Nr. 4, , P. 1181–1188
