Innovative analytics for health research

New findings about the composition, structure and dynamics of new materials and biological systems can only be obtained by developing innovative analytical (measuring) processes. The knowledge gained in this manner is crucial for deepening our understanding of the causes of disease on a molecular level, paves the way to more precise, personalized medical treatments, and is a key to the characterization and development of new, treatment-improving materials; it calls for and is subject to a constant process of optimization.

The scientific work at ISAS concerns the development of new methods on all levels – from basic research through to the production of prototypes. The following pages will provide you with detailed information about our research topics and projects.

Research programmes

Disease Mechanisms and Targets

The projects in the Disease Mechanisms and Targets programme focus on a central aspect of health research: the investigation of molecular mechanisms that are involved in pathogenesis.

The projects in the Biomarkers programme focus on the identification and validation of biomarkers as well as on the improved detection of such molecules in a complex biological matrix.

ISAS uses its long-standing experience in optical spectroscopy to develop its methods towards imaging applications for health research. In the Imaging programme, methods such as Raman spectroscopy, high-resolution fluorescence, or CARS microscopy are combined to develop novel analytical platforms.

The projects in this programme focus on non-destructive and non-invasive analytical methods for minute samples of biomolecules on solid-liquid surfaces. Such biohybrid interfaces are especially suited for sensors or for studying biomolecular interactions, cell templates, and biomolecule binding to surfaces.

The objective of the Strategy Fund “Competition” is to promote scientific ideas that particularly support the strategic aims of ISAS. For this internal competition, the institute has established the funding lines “Integrative Research” and “Early Independence”, which are advertised alternately.

Recent publications

Hoffmann N, Kopczynski D, Al Machot F, Schwudke D, Miranda Ackermann J, Shevchenko A, Ahrends R.

Lipidomics – How Lipids Control Blood Coagulation

2020

Book series: DATA ANALYSIS FOR INSIGHTS INTO COMPLEX BIOLOGICAL SYSTEMS

Type: Book contribution

Hack T, Bertram S, Blair H, Borger V, Busche G, Denson L, Fruth E, Giebel B, Heidenreich O, Klein-Hitpass L, Kollipara L, Sendker S, Sickmann A, Walter C, von Neuhoff N, Hanenberg H, Reinhardt D, Schneider M, Rasche M.

Exposure of patient-derived mesenchymal stromal cells to TGFB1 supports fibrosis induction in a pediatric acute megakaryoblastic leukemia model

Molecular Cancer Research, Vol. 18, Nr. 10, 2020, P. 1603–1612

Type: Journal article

DOI: /doi.org/10.1158/1541-7786.MCR-20-0091

Metzger P, Kirchleitner SV, Boehmer DFR, Hörth C, Eisele A, Ormanns S, Gunzer M, Lech M, Lauber K, Endres S, Duewell P, Schnurr M, König LM.

Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model

Cancer Immunology, Immunotherapy, Vol. 69, Nr. 10, 2020, P. 2101–2112

Type: Journal article

DOI: /doi.org/10.1007/s00262-020-02605-9

Kopczynski D, Hentschel A, Coman C, Schebb NH, Hornemann T, Mashek D, Hartung NM, Shevchuk O, Schött HF, Lorenz K, Torta F, Burla B, Zahedi RP, Sickmann A, Kreutz MR, Ejsing C, Medenbach J, Ahrends R.

Simple targeted assays for metabolic pathways and signaling: a powerful tool for targeted proteomics

Analytical Chemistry, Vol. 2020, 2020

Type: Journal article

DOI: /doi.org/10.1021/acs.analchem.0c02793

Mailer RK, Allende M, Heestermans M, Schweizer M, Deppermann C, Frye M, Pula G, Odeberg J, Gelderblom MP, Rose-John S, Sickmann A, Blankenberg S, Huber TB, Kubisch C, Maas C, Gambaryan S, Firsov D, Stavrou EX, Butler L, Renné T.

Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate

Blood, 2020

Type: Journal article

DOI: /doi.org/10.1182/blood.2019004617

Koenig M, Trouillet V, Welle A, Hinrichs K, Lahann J.

Molecular Changes in Vapor-based Polymer Thin Films Assessed by Characterization of Swelling Properties of Amine-Functionalized Poly-p-xylylene

Macromolecular Chemistry and Physics, Vol. 2020, Nr. 221, 2020

Type: Journal article

DOI: /doi.org/10.1002/macp.202000213

More publications

Innovative analytics
for health research

Research programmes

Disease Mechanisms and Targets

Biomarkers

Imaging

Biointerfaces

ISAS Strategy Fund

Recent publications

Lipidomics – How Lipids Control Blood Coagulation

Exposure of patient-derived mesenchymal stromal cells to TGFB1 supports fibrosis induction in a pediatric acute megakaryoblastic leukemia model

Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model

Simple targeted assays for metabolic pathways and signaling: a powerful tool for targeted proteomics

Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate

Molecular Changes in Vapor-based Polymer Thin Films Assessed by Characterization of Swelling Properties of Amine-Functionalized Poly-p-xylylene