Innovative analytics
for health research

New findings about the composition, structure and dynamics of new materials and biological systems can only be obtained by developing innovative analytical (measuring) processes. The knowledge gained in this manner is crucial for deepening our understanding of the causes of disease on a molecular level, paves the way to more precise, personalized medical treatments, and is a key to the characterization and development of new, treatment-improving materials; it calls for and is subject to a constant process of optimization.

The scientific work at ISAS concerns the development of new methods on all levels – from basic research through to the production of prototypes. The following pages will provide you with detailed information about our research topics and projects.

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Research programmes

Disease Mechanisms and Targets

Disease Mechanisms and Targets

The projects in the Disease Mechanisms and Targets programme focus on a central aspect of health research: the investigation of molecular mechanisms that are involved in pathogenesis.

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Biomarkers

Biomarkers

The projects in the Biomarkers programme focus on the identification and validation of biomarkers as well as on the improved detection of such molecules in a complex biological matrix.

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Biointerfaces

Biointerfaces

The projects in this programme focus on non-destructive and non-invasive analytical methods for minute samples of biomolecules on solid-liquid surfaces. Such biohybrid interfaces are especially suited for sensors or for studying biomolecular interactions, cell templates, and biomolecule binding to surfaces.

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Imaging

Imaging

ISAS uses its long-standing experience in optical spectroscopy to develop its methods towards imaging applications for health research. In the Imaging programme, methods such as Raman spectroscopy, high-resolution fluorescence, or CARS microscopy are combined to develop novel analytical platforms.

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ISAS Strategy Fund

ISAS Strategy Fund

The objective of the Strategy Fund “Competition” is to promote scientific ideas that particularly support the strategic aims of ISAS. For this internal competition, the institute has established the funding lines “Integrative Research” and “Early Independence”, which are advertised alternately.

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Recent publications

How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency

International Journal of Molecular Sciences, Vol. 20, Nr. 9,
Type: Journal article
DOI: /doi.org/10.3390/ijms20092179

Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation

Scientific reports, Vol. 9, Nr. 1, , P. 1–12
Type: Journal article
DOI: /doi.org/10.1038/s41598-019-42263-1

SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human

Neurobiology of Disease, Vol. 124, , P. 218–229
Type: Journal article
DOI: /doi.org/10.1016/j.nbd.2018.11.019

Analyte-Tailored Controlled Atmosphere Improves Dielectric Barrier Discharge Ionization Mass Spectrometry Performance

Analytical Chemistry, Vol. 91, Nr. 5, , P. 3733–3739
Type: Journal article
DOI: /doi.org/10.1021/acs.analchem.9b00112

Arylic vs. Alkylic - Hydrophobic Linkers Determine Supramolecular Structure and Optoelectronic Properties of Tripodal Amphiphilic Push-Pull-Thiazoles

Langmuir, Vol. 35, Nr. 7, , P. 2561–2570
Type: Journal article
DOI: /doi.org/10.1021/acs.langmuir.8b03893

Second exposure to acetaminophen overdose is associated with liver fibrosis in mice

EXCLI Journal, Vol. 18, , P. 51–62
Type: Journal article
DOI: /doi.org/10.17179/excli2018-1920

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