Innovative analytics for health research

New findings about the composition, structure and dynamics of new materials and biological systems can only be obtained by developing innovative analytical (measuring) processes. The knowledge gained in this manner is crucial for deepening our understanding of the causes of disease on a molecular level, paves the way to more precise, personalized medical treatments, and is a key to the characterization and development of new, treatment-improving materials; it calls for and is subject to a constant process of optimization.

The scientific work at ISAS concerns the development of new methods on all levels – from basic research through to the production of prototypes. The following pages will provide you with detailed information about our research topics and projects.

Research programmes

Disease Mechanisms and Targets

The projects in the Disease Mechanisms and Targets programme focus on a central aspect of health research: the investigation of molecular mechanisms that are involved in pathogenesis.

The projects in the Biomarkers programme focus on the identification and validation of biomarkers as well as on the improved detection of such molecules in a complex biological matrix.

ISAS uses its long-standing experience in optical spectroscopy to develop its methods towards imaging applications for health research. In the Imaging programme, methods such as Raman spectroscopy, high-resolution fluorescence, or CARS microscopy are combined to develop novel analytical platforms.

The projects in this programme focus on non-destructive and non-invasive analytical methods for minute samples of biomolecules on solid-liquid surfaces. Such biohybrid interfaces are especially suited for sensors or for studying biomolecular interactions, cell templates, and biomolecule binding to surfaces.

The objective of the Strategy Fund “Competition” is to promote scientific ideas that particularly support the strategic aims of ISAS. For this internal competition, the institute has established the funding lines “Integrative Research” and “Early Independence”, which are advertised alternately.

Recent publications

Raschke H, Hergenröder R.

Tuning the Surface Chemistry of Melanin-Mimetic Polydopamine Nanoparticles Drastically Enhances Their Accumulation into Excised Human Skin

ACS Biomaterials Science & Engineering, Vol. 2020, 2020, P. 4424–4432

Type: Journal article

DOI: /doi.org/10.1021/acsbiomaterials.0c00196

Ebersbach P, Münchberg U, Freier E.

SERS background imaging – A versatile tool towards more reliable SERS analytics

Research Square, 2020

Type: Journal article

DOI: /doi.org/10.21203/rs.3.rs-41355/v1

Sims MC, Mayer L, Collins J, Bariana T, Megy K, Lavenu-Bombled C, Seyres D, Kollipara L, Burden F, Greene D, Lee D, Rodriguez-Romera A, Alessi MC, Astle WJ, Bahou W, Bury L, Chalmers E, Da Silva R, De Candia E, Deevi SVV, Farrow S, Gomez K, Grassi L, Greinacher A, Gresele P, Hart DP, Hurtaud MF, Kelly A, Kerr R, Le Quellec S, Leblanc TM, Leinøe EB, Mapeta RP, McKinney H, Michelson AD, Morais S, Nugent DJ, Papadia S, Park SJ, Pasi J, Podda GM, Poon MC, Reed R, Sekhar M, Shalev H, Sivapalaratnam S, Steinberg-Shemer O, Stephens JC, Tait RC, Turro E, Wu JK, Zieger BMH, Kuijpers TW, Whetton AD, Sickmann A, Freson K, Downes K, Erber W, Frontini M, Nurden P, Ouwehand WH, Favier R, Guerrero JA.

Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome

Blood, 2020

Type: Journal article

DOI: /doi.org/10.1182/blood.2019004776

Bornemann L, Schuster M, Schmitz S, Sobczak C, Bessen C, Merz SF, Jöckel KH, Haverkamp T, Gunzer M, Göthert JR.

Defective migration and dysmorphology of neutrophil granulocytes in atypical chronic myeloid leukemia treated with ruxolitinib

BMC cancer, Vol. 20, Nr. 1, 2020, P. 650

Type: Journal article

DOI: /doi.org/10.1186/s12885-020-07130-7

Hinrichs K, Kratz C, Furchner A.

Hyperspectral mid-infrared ellipsometric measurements in the twinkling of an eye

Spectroscopy Asia, Vol. 16, Nr. 2, 2020, P. 8–12

Type: Journal article

DOI: /doi.org/https://www.spectroscopyasia.com/content/volume-16-issue-2-2020

Furchner A, Kratz C, Hinrichs K.

Laser IR ellipsometry for surface analytics - Hyperspectral and microfluidic applications

2020

Book series: Laser IR ellipsometry for surface analytics

Type: Book contribution

DOI: /doi.org/https://analyticalscience.wiley.com/do/10.1002/was.00080139

More publications

Innovative analytics
for health research

Research programmes

Disease Mechanisms and Targets

Biomarkers

Imaging

Biointerfaces

ISAS Strategy Fund

Recent publications

Tuning the Surface Chemistry of Melanin-Mimetic Polydopamine Nanoparticles Drastically Enhances Their Accumulation into Excised Human Skin

SERS background imaging – A versatile tool towards more reliable SERS analytics

Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome

Defective migration and dysmorphology of neutrophil granulocytes in atypical chronic myeloid leukemia treated with ruxolitinib

Hyperspectral mid-infrared ellipsometric measurements in the twinkling of an eye

Laser IR ellipsometry for surface analytics - Hyperspectral and microfluidic applications