New findings about the composition, structure and dynamics of new materials and biological systems can only be obtained by developing innovative analytical (measuring) processes. The knowledge gained in this manner is crucial for deepening our understanding of the causes of disease on a molecular level, paves the way to more precise, personalized medical treatments, and is a key to the characterization and development of new, treatment-improving materials; it calls for and is subject to a constant process of optimization.
The scientific work at ISAS concerns the development of new methods on all levels – from basic research through to the production of prototypes. The following pages will provide you with detailed information about our research topics and projects.
Research programmes
Disease Mechanisms & Targets
This research programme focuses on the analysis of molecular mechanisms involved in the development of various diseases, such as cardiovascular diseases.
In order to understand when and where in the body the biological decision between disease and health is made, analytical methods are needed that map information on different classes of molecules and their spatial distribution patterns simultaneously. The aim of the work in the research programme is to determine biomarkers for early diagnoses or personalised therapy with the help of 4D analytics.
ISAS uses its long-standing experience in optical spectroscopy to develop its methods towards imaging applications for health research. In the Imaging programme, methods such as Raman spectroscopy, high-resolution fluorescence, or CARS microscopy are combined to develop novel analytical platforms.
The objective of the Strategy Fund “Competition” is to promote scientific ideas that particularly support the strategic aims of ISAS. For this internal competition, the institute has established the funding lines “Integrative Research” and “Early Independence”, which are advertised alternately.
Mohamud Yusuf A,
Hagemann N,
Zhang X,
Zafar M,
Hussner T,
Bromkamp C,
Martiny C,
Tertel T,
Börger V,
Schumacher F,
Solari F,
Hasenberg M,
Kleinschnitz C,
Doeppner TR,
Kleuser B,
Sickmann A,
Gunzer M,
Giebel B,
Kolesnick R,
Gulbins E,
Hermann DM.
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles
Pylaeva E,
Korschunow G,
Spyra I,
Bordbari S,
Siakaeva E,
Ozel I,
Domnich M,
Squire A,
Hasenberg A,
Thangavelu K,
Hussain T,
Goetz M,
Lang KS,
Gunzer M,
Hansen W,
Buer J,
Bankfalvi A,
Lang S,
Jablonska J.
During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes
