Biospectroscopy

In the Biospectroscopy Research Department, we set ourselves the goal of improving early detection of diseases, especially of the cardiovascular system and for tumors. Our aim is to improve the assessment of individual risks in existing diagnoses with the help of modern imaging techniques. Starting from experimental model systems, we first investigate the complex biochemical and cellular basis of diseases in different phases of their development and then transfer the results to the human body.
State-of-the-art imaging techniques play an important role in this procedure. We use different methods of mesoscopic and high-resolution 3-D microscopy to visualize cellular and biophysical processes in intact tissue and whole organs. These results are combined with innovative analytical methods developed at ISAS in order to make all relevant biomolecule classes measurable without markers.

The result is a comprehensive description of the state of complex biological systems under physiological and pathological conditions.
With such a combination of modern imaging and molecular analysis, we are able to capture all orders of magnitude from molecules to supracellular structures required for spatially and temporally resolved analysis. The findings on biological systems gained from this holistic approach will then help to develop new tailor-made prevention and therapy measures.

The department was established in August 2019 and is currently being built.

 

Current Publications

Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model

Cancer Immunology, Immunotherapy, Vol. 69, Nr. 10, , P. 2101–2112
Type: Journal article

Defective migration and dysmorphology of neutrophil granulocytes in atypical chronic myeloid leukemia treated with ruxolitinib

BMC cancer, Vol. 20, Nr. 1, , P. 650
Type: Journal article

Community standards for open cell migration data

GigaScience, Vol. 9, Nr. 5,
Type: Journal article

Three-Dimensional Light Sheet Fluorescence Microscopy of Lungs To Dissect Local Host Immune-Aspergillus fumigatus interactions

mBio, Vol. 11, Nr. 1, , P. e02752–19
Type: Journal article