In the Biospectroscopy Research Department, we set ourselves the goal of improving early detection of diseases, especially of the cardiovascular system and for tumors. Our aim is to improve the assessment of individual risks in existing diagnoses with the help of modern imaging techniques. Starting from experimental model systems, we first investigate the complex biochemical and cellular basis of diseases in different phases of their development and then transfer the results to the human body.
State-of-the-art imaging techniques play an important role in this procedure. We use different methods of mesoscopic and high-resolution 3-D microscopy to visualize cellular and biophysical processes in intact tissue and whole organs. These results are combined with innovative analytical methods developed at ISAS in order to make all relevant biomolecule classes measurable without markers.

The result is a comprehensive description of the state of complex biological systems under physiological and pathological conditions.
With such a combination of modern imaging and molecular analysis, we are able to capture all orders of magnitude from molecules to supracellular structures required for spatially and temporally resolved analysis. The findings on biological systems gained from this holistic approach will then help to develop new tailor-made prevention and therapy measures.

The department was established in August 2019 and is currently being built.


Current Publications

Molecular pathophysiology of human MICU1-deficiency

Neuropathology and applied neurobiology, Vol. 47, Nr. 6, , P. 840–855
Type: Journal article

Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy

European heart journal, Vol. ehab430,
Type: Journal article

Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke

Brain behavior and immunity, Vol. 93, , P. 277–287
Type: Journal article

Advances in the In Vivo Molecular Imaging of Invasive Aspergillosis

Journal of fungi, Vol. 6, Nr. 4, , P. 1–15
Type: Journal article

Co-option of Neutrophil Fates by Tissue Environments

Cell, Vol. 183, Nr. 5, , P. 1282–1297.e18
Type: Journal article

Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia

Basic Research in Cardiology, Vol. 115, Nr. 6, , P. 64
Type: Journal article