ERC-Sulfaging

The research group ERC-Sulfaging investigates the connection between ageing processes and so-called gasotransmitter signalling. The researchers focus on the signal transmission in cells via hydrogen sulfide.

In this young field of research, the researchers want to decode the exact mechanisms of hydrogen sulfide actions, for example with the help of worms. Their work on metabolic biochemistry provides important insights, for example for a better diagnosis and treatment of age-related diseases in the future. For this purpose, the European Research Council (ERC) has awarded Dr habil. Miloš Filipović the Consolidator Grant.

This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 864921).

Current Publications

Moparthi L, Sinica V, Moparthi VK, Kreir M, Vignane T, Filipovic MR, Vlachova V, Zygmunt PM.

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Nature Communications, Vol. 13, Nr. 1, 2022, P. 6113

Type: Journal article

DOI: /doi.org/10.1038/s41467-022-33876-8

Stoeckl SK, de Col R, Filipovic MR, Messlinger K.

Nitroxyl Delivered by Angeli's Salt Causes Short-Lasting Activation Followed by Long-Lasting Deactivation of Meningeal Afferents in Models of Headache Generation

International Journal of Molecular Sciences, Vol. 23, Nr. 4, 2022

Type: Journal article

DOI: /doi.org/10.3390/ijms23042330

Statzer C, Meng J, Venz R, Bland M, Robida-Stubbs S, Patel K, Petrovic D, Emsley R, Liu P, Morantte I, Haynes C, Mair WB, Longchamp A, Filipovic MR, Blackwell TK, Ewald CY.

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

Nature Communications, Vol. 13, Nr. 1, 2022, P. 967

Type: Journal article

DOI: /doi.org/10.1038/s41467-022-28599-9

Aroca A, Jurado-Flores A, Filipovic MR, Gotor C, Romero LC.

Detection of protein persulfidation in plants by the dimedone switch method

Methods in enzymology, Vol. 676, 2022, P. 385–402

Type: Journal article

DOI: /doi.org/10.1016/bs.mie.2022.07.024

Ok K, Filipovic MR, Michel SLJ.

Targeting Zinc Finger Proteins with Exogenous Metals and Molecules

European Journal of Inorganic Chemistry, Vol. 2021, Nr. 37, 2021, P. 3795–3805

Type: Journal article

DOI: /doi.org/10.1002/ejic.202100402

Petrovic D, Kouroussis E, Vignane T, Filipovic MR.

The Role of Protein Persulfidation in Brain Aging and Neurodegeneration

Frontiers in Aging Neuroscience, Vol. 13, 2021, P. 674135

Type: Journal article

DOI: /doi.org/10.3389/fnagi.2021.674135