Translational Analytics

The analytical concepts worked out in the Bioanalytics department, for instance for the analysis of the platelet proteome, will be standardised, certified, and made ready for the market in an independent work group (funded by the state of North Rhine-Westphalia, Ministry of Innovation, Science and Research). The aim of the Standardisation group is the application of omics technologies to patient samples in the scope of research studies, in order to identify biomarkers for individual risk prediction and prevention of cardio­vascular diseases such as blood clotting disorders, strokes, heart attacks, or venous thromboses.

The group was established in 2015 and is currently preparing the accreditation of their test laboratory according to ISO17025 by the DAkkS (Deutsche Akkreditierungsstelle), which is planned for 2019. The standardisation, validation, and accreditation of processes, personnel, methods, and facilities enables the group to deliver mass spectrometry methods developed at ISAS to its partners in research and clinics, providing high quality methods that are ready for practical use. The group therefore serves as a link between the institute's often very basic research and the demands of stakeholders with regard to putting novel technologies into everyday operation.

Current Publications

Endoplasmic reticulum-stress and unfolded protein response-activation in immune-mediated necrotizing myopathy

Brain pathology, Vol. 32, Nr. 6, , P. e13084
Type: Journal article

The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro

Archives of Toxicology, Vol. 96, Nr. 8, , P. 2341–2360
Type: Journal article

Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naive Human BMSCs

Cells, Vol. 11, Nr. 16,
Type: Journal article

Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naive Human BMSCs

Cells, Vol. 11, Nr. 16,
Type: Journal article

Cathepsin D as biomarker in cerebrospinal fluid of nusinersen‐treated patients with spinal muscular atrophy

European Journal of Neurology, Vol. 29, Nr. 7, , P. 2084–2096
Type: Journal article

Proteomic and morphological insights and clinical presentation of two young patients with novel mutations of BVES (POPDC1)

Molecular genetics and metabolism, Vol. 136, Nr. 3, , P. 226–237
Type: Journal article