Standardisation

The analytical concepts worked out in the Bioanalytics department, for instance for the analysis of the platelet proteome, will be standardised, certified, and made ready for the market in an independent work group (funded by the state of North Rhine-Westphalia, Ministry of Innovation, Science and Research). The aim of the Standardisation group is the application of omics technologies to patient samples in the scope of research studies, in order to identify biomarkers for individual risk prediction and prevention of cardio­vascular diseases such as blood clotting disorders, strokes, heart attacks, or venous thromboses.

The group was established in 2015 and is currently preparing the accreditation of their test laboratory according to ISO17025 by the DAkkS (Deutsche Akkreditierungsstelle), which is planned for 2019. The standardisation, validation, and accreditation of processes, personnel, methods, and facilities enables the group to deliver mass spectrometry methods developed at ISAS to its partners in research and clinics, providing high quality methods that are ready for practical use. The group therefore serves as a link between the institute's often very basic research and the demands of stakeholders with regard to putting novel technologies into everyday operation.

Current Publications

Characterization of Naïve and Vitamin C-Treated Mouse Schwann Cell Line MSC80

Journal of Proteome Research, Vol. 17, Nr. 9,
Type: Journal article

Platelet proteomics: from discovery to diagnosis

Expert Review of Proteomics, Vol. 15, Nr. 6, , P. 1–10
Type: Journal article

Identification and characterization of the BRI2 interactome in the brain

Scientific reports, Vol. 8, Nr. 1, , P. 3548
Type: Journal article

Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry

Proteomes, Vol. 5, Nr. 4,
Type: Journal article

Combining De Novo Peptide Sequencing Algorithms, A Synergistic Approach to Boost Both Identifications and Confidence in Bottom-up Proteomics

Journal of Proteome Research, Vol. 16, Nr. 9, , P. 3209–3218
Type: Journal article

LMD proteomics provides evidence for hippocampus field-specific motor protein abundance changes with relevance to Alzheimer's disease

Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, Vol. 1865, Nr. 6, , P. 703–714
Type: Journal article