Proteomics

The Proteomics group aims at describing and understanding biological systems at different levels of complexity. To this end, it develops methods to qualitatively and quantitatively detect biomolecules, particularly proteins.

The group is concerned both with the structure of proteins and with the dynamic changes triggered by external influences, metabolic processes and communication processes in cells. These play a role in almost all diseases – including common illnesses, such as cardiovascular diseases, cancer and diabetes. The potential applications for this work therefore extend from purely basic research through to new developments for medical diagnostics. An important aspect in this context is a targeted, personalised treatment of illnesses. However, such a therapy approach is not possible until it is known precisely where and how which (bio-)molecule acts inside the cell, how it is transported and where it binds; in other words, how the biological system works as a whole.

Current Publications

Future perspectives on in-vitro diagnosis of drug allergy by the lymphocyte transformation test

Journal of immunological methods, Vol. 495, , P. 113072
Type: Journal article

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Nature Communications, Vol. 12, Nr. 1,
Type: Journal article

Probes for Photoaffinity Labelling of Kinases

ChemBioChem, Vol. 22, Nr. 13, , P. 2206–2218
Type: Journal article

Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions

Scientific reports, Vol. 11, Nr. 1,
Type: Journal article

A patient-based medaka alg2 mutant as a model for hypo-N-glycosylation

Development, Vol. 148, Nr. 11,
Type: Journal article

Lymphocyte transformation test

Journal of immunological methods, Vol. 493,
Type: Journal article