Proteomics

The Proteomics group aims at describing and understanding biological systems at different levels of complexity. To this end, it develops methods to qualitatively and quantitatively detect biomolecules, particularly proteins.

The group is concerned both with the structure of proteins and with the dynamic changes triggered by external influences, metabolic processes and communication processes in cells. These play a role in almost all diseases – including common illnesses, such as cardiovascular diseases, cancer and diabetes. The potential applications for this work therefore extend from purely basic research through to new developments for medical diagnostics. An important aspect in this context is a targeted, personalised treatment of illnesses. However, such a therapy approach is not possible until it is known precisely where and how which (bio-)molecule acts inside the cell, how it is transported and where it binds; in other words, how the biological system works as a whole.

Current Publications

Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain

Journal of Medicinal Chemistry, Vol. 65, Nr. 20, , P. 13660–13680
Type: Journal article

Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles

Basic Research in Cardiology, Vol. 117, Nr. 1,
Type: Journal article

The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro

Archives of Toxicology, Vol. 96, Nr. 8, , P. 2341–2360
Type: Journal article

Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear

International Journal of Molecular Sciences, Vol. 23, Nr. 15, , P. 8688
Type: Journal article

Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells

Respiratory research, Vol. 23, Nr. 1, , P. 191
Type: Journal article

Combinatorial Optimization of Activity-Based Probes for Acyl Protein Thioesterases 1 and 2

ACS Medicinal Chemistry Letters, Vol. 13, Nr. 7, , P. 1144–1150
Type: Journal article