Protein Dynamics

The Protein Dynamics group aims to describe and understand biological systems at different levels of complexity. To this end, it develops methods to qualitatively and quantitatively detect biomolecules, particularly proteins.

The group is concerned both with the structure of proteins and with the dynamic changes triggered by external influences, metabolic processes and communication processes in cells. These play a role in almost all diseases – including common illnesses, such as cardiovascular diseases, cancer and diabetes. The potential applications for this work therefore extend from purely basic research through to new developments for medical diagnostics. An important aspect in this context is a targeted, personalised treatment of illnesses. However, such a therapy approach is not possible until it is known precisely where and how which (bio-)molecule acts inside the cell, how it is transported and where it binds; in other words, how the biological system works as a whole.

Current Publications

Proteogenomics of Colorectal Cancer Liver Metastases

Cancers, Vol. 11, Nr. 12,
Type: Journal article

Combination of Proteogenomics with Peptide De Novo Sequencing Identifies New Genes and Hidden Posttranscriptional Modifications

mBio,
Type: Journal article

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S

Chemical Science, Vol. 2019, Nr. 46, , P. 10789–10801
Type: Journal article

A sensitive and simple targeted proteomics approach to quantify transcription factor and membrane proteins of the unfolded protein response pathway in glioblastoma cells

Scientific reports, Vol. 9,
Type: Journal article

Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique

Nature Communications, Vol. 2019, Nr. 10(1), , P. 1–12
Type: Journal article

Separation and Identification of Non-Covalent Metal Complexes from Bacteria by HILIC–MS

LC-GC North America, Vol. 36, Nr. 3, , P. 165–166
Type: Journal article