Proteomics

The Proteomics group aims at describing and understanding biological systems at different levels of complexity. To this end, it develops methods to qualitatively and quantitatively detect biomolecules, particularly proteins.

The group is concerned both with the structure of proteins and with the dynamic changes triggered by external influences, metabolic processes and communication processes in cells. These play a role in almost all diseases – including common illnesses, such as cardiovascular diseases, cancer and diabetes. The potential applications for this work therefore extend from purely basic research through to new developments for medical diagnostics. An important aspect in this context is a targeted, personalised treatment of illnesses. However, such a therapy approach is not possible until it is known precisely where and how which (bio-)molecule acts inside the cell, how it is transported and where it binds; in other words, how the biological system works as a whole.

Current Publications

The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro

Archives of Toxicology, Vol. 96, Nr. 8, , P. 2341–2360
Type: Journal article

CARS Imaging Advances Early Diagnosis of Cardiac Manifestation of Fabry Disease

International Journal of Molecular Science, Vol. 23, Nr. Special Issue,
Type: Journal article

Toward Zero Variance in Proteomics Sample Preparation

Journal of Proteome Research, Vol. 21, Nr. 4, , P. 1181–1188
Type: Journal article

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression

RNA, , P. rna.079086.121
Type: Journal article

Novel insights into PORCN mutations, associated phenotypes and pathophysiological aspects

Orphanet journal of rare diseases, Vol. 17, Nr. 1,
Type: Journal article

Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets

International Journal of Molecular Sciences, Vol. 2022, Nr. 23 (3),
Type: Journal article