Proteomics

The Proteomics group aims at describing and understanding biological systems at different levels of complexity. To this end, it develops methods to qualitatively and quantitatively detect biomolecules, particularly proteins.

The group is concerned both with the structure of proteins and with the dynamic changes triggered by external influences, metabolic processes and communication processes in cells. These play a role in almost all diseases – including common illnesses, such as cardiovascular diseases, cancer and diabetes. The potential applications for this work therefore extend from purely basic research through to new developments for medical diagnostics. An important aspect in this context is a targeted, personalised treatment of illnesses. However, such a therapy approach is not possible until it is known precisely where and how which (bio-)molecule acts inside the cell, how it is transported and where it binds; in other words, how the biological system works as a whole.

Current Publications

Toward Zero Variance in Proteomics Sample Preparation

Journal of Proteome Research, Vol. 21, Nr. 4, , P. 1181–1188
Type: Journal article

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression

RNA, , P. rna.079086.121
Type: Journal article

Novel insights into PORCN mutations, associated phenotypes and pathophysiological aspects

Orphanet journal of rare diseases, Vol. 17, Nr. 1,
Type: Journal article

Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets

International Journal of Molecular Sciences, Vol. 2022, Nr. 23 (3),
Type: Journal article

Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation

iScience, Vol. 25, Nr. 1, , P. 103718
Type: Journal article

Galectin-9 activates platelet ITAM receptors glycoprotein VI and C-type lectin-like receptor-2

Journal of Thrombosis and Haemostasis : JTH, , P. 1–15
Type: Journal article