Bioanalytics

Our work in the Bioanalytics department involves trying to understand the highly complex signalling and metabolic pathways in cells and cell layers in the human body at different levels, from lipids through to intercellular communication processes. Our long-term objective is to improve the health of the general public. To this end, we develop techniques to measure molecule diffusion with spatial and temporal resolution. We hope that these measurement techniques and the results of analyses can be used to help diagnose a variety of illnesses more easily – such as cardiovascular diseases - and perhaps even to develop new therapies. 

In order to explain the multitude of single processes in as much detail and as reliably as possible, we work on living cells and with microchips on which the transport and signalling paths of human cells are simulated.

Current Publications

Combination of Proteogenomics with Peptide De Novo Sequencing Identifies New Genes and Hidden Posttranscriptional Modifications

mBio,
Type: Journal article

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart from Failure

Circulation Research, Nr. 7, , P. 580–594
Type: Journal article

A sensitive and simple targeted proteomics approach to quantify transcription factor and membrane proteins of the unfolded protein response pathway in glioblastoma cells

Scientific reports, Vol. 9,
Type: Journal article

Short Peptides with Uncleavable Peptide Bond Mimetics as Photoactivatable Caspase-3 Inhibitors

Molecules, Vol. 24, Nr. 1,
Type: Journal article

Activation of E2F-dependent transcription by the mouse cytomegalovirus M117 protein affects the viral host range

PLoS Pathogens, Vol. 14, Nr. 12,
Type: Journal article

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

Cell Metabolism, Vol. 28, Nr. 6, , P. 866–880
Type: Journal article