Bioanalytics

Our work in the Bioanalytics department involves trying to understand the highly complex signalling and metabolic pathways in cells and cell layers in the human body at different levels, from lipids through to intercellular communication processes. Our long-term objective is to improve the health of the general public. To this end, we develop techniques to measure molecule diffusion with spatial and temporal resolution. We hope that these measurement techniques and the results of analyses can be used to help diagnose a variety of illnesses more easily – such as cardiovascular diseases - and perhaps even to develop new therapies. 

In order to explain the multitude of single processes in as much detail and as reliably as possible, we work on living cells and with microchips on which the transport and signalling paths of human cells are simulated.

Current Publications

Generation of a humanized FXII knock-in mouse-A powerful model system to test novel anti-thrombotic agents

Journal of Thrombosis and Haemostasis : JTH, Vol. 19, Nr. 11, , P. 2835–2840
Type: Journal article

Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability

Molecular metabolism, , P. 101359
Type: Journal article

Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involvement

The Journal of pathology,
Type: Journal article

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Nature Communications, Vol. 12, Nr. 1,
Type: Journal article

Molecular Proteomics and Signalling of Human Platelets in Health and Disease

International Journal of Molecular Sciences, Vol. 22, Nr. 18,
Type: Journal article

MARCKS affects cell motility and response to BTK inhibitors in CLL

Blood, Vol. 138, Nr. 7, , P. 544–556
Type: Journal article