Bioanalytics

Our work in the Bioanalytics department involves trying to understand the highly complex signalling and metabolic pathways in cells and cell layers in the human body at different levels, from lipids through to intercellular communication processes. Our long-term objective is to improve the health of the general public. To this end, we develop techniques to measure molecule diffusion with spatial and temporal resolution. We hope that these measurement techniques and the results of analyses can be used to help diagnose a variety of illnesses more easily – such as cardiovascular diseases - and perhaps even to develop new therapies. 

In order to explain the multitude of single processes in as much detail and as reliably as possible, we work on living cells and with microchips on which the transport and signalling paths of human cells are simulated.

Current Publications

Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets

Haematologica, Vol. 105, Nr. 6, , P. 1667–1676
Type: Journal article

Improving Identification of In-organello Protein-Protein Interactions Using an Affinity-enrichable, Isotopically Coded, and Mass Spectrometry-cleavable Chemical Crosslinker

Molecular & Cellular Proteomics, Vol. 19, Nr. 4, , P. 624–639
Type: Journal article

Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum

Proteomics, , P. e1900104
Type: Journal article

Phosphoproteomic analysis of STRIPAK mutants identifies a conserved serine phosphorylation site in PAK kinase CLA4 to be important in fungal sexual development and polarized growth

Molecular Microbiology, Vol. 113, Nr. 6, , P. 1053–1069
Type: Journal article

Lipidomik: wie Lipide die Blutgerinnung steuern

Book series: de.NBI Use Case Broschüre 2020
Type: Book contribution

Proteogenomics of Colorectal Cancer Liver Metastases

Cancers, Vol. 11, Nr. 12,
Type: Journal article