Bioanalytics

Our work in the Bioanalytics department involves trying to understand the highly complex signalling and metabolic pathways in cells and cell layers in the human body at different levels, from lipids through to intercellular communication processes. Our long-term objective is to improve the health of the general public. To this end, we develop techniques to measure molecule diffusion with spatial and temporal resolution. We hope that these measurement techniques and the results of analyses can be used to help diagnose a variety of illnesses more easily – such as cardiovascular diseases - and perhaps even to develop new therapies. 

In order to explain the multitude of single processes in as much detail and as reliably as possible, we work on living cells and with microchips on which the transport and signalling paths of human cells are simulated.

Current Publications

BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation

The Journal of Clinical Investigation, Vol. 130, Nr. 11, , P. 6064–6079
Type: Journal article

Cutting the Gordian knot: early and complete amino acid sequence confirmation of class II lasso peptides by HCD fragmentation

The Journal of Antibiotics, Vol. 73, Nr. 11, , P. 772–779
Type: Journal article

Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome

Blood, Vol. 136, Nr. 17, , P. 1956–1967
Type: Journal article

Exposure of patient-derived mesenchymal stromal cells to TGFB1 supports fibrosis induction in a pediatric acute megakaryoblastic leukemia model

Molecular Cancer Research, Vol. 18, Nr. 10, , P. 1603–1612
Type: Journal article

The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes

Plos genetics, Vol. 16, Nr. 9, , P. e1008819
Type: Journal article

Simple targeted assays for metabolic pathways and signaling: a powerful tool for targeted proteomics

Analytical Chemistry, Vol. 92, Nr. 20, , P. 13672–13676
Type: Journal article