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Dortmund, 4th May 2023

Damit die Proteine im Massenspektrometer analysiert werden können, trennt Joy Amrei Brummel sie an der Zentrifuge aus den Proben heraus.
© ISAS - Joy Amrei Brummel purifies the thrombocytes at the centrifuge and isolates the cells for analysis in the mass spectrometer.

Joy Amrei Brummel (24) is studying Chemical Biology at TU Dortmund. Since her initiative application at ISAS in May 2022, she has been working as a student assistant in the Proteomics research group alongside her university studies. She is also writing her master’s thesis at ISAS. To learn more about her work in the laboratory, the editorial team asked her to complete the following sentences.

  • As a student assistant in the Proteomics research group…

    I help prepare samples for mass spectrometric analysis. I also assist my colleagues in the lab. For example, I take inventory of the samples in storage or prepare buffers, chemical solutions that maintain the stable pH value in a sample. It’s great to apply the methods you learned about in theory during your studies in an intensive and practical manner here.

  • My bachelor thesis deals with…

    the topic of thrombosis. More precisely, it’s about the mass spectrometric analysis of proteins during the activation of blood platelets (thrombocytes). This causes the platelets to clump together and a blood clot (thrombus) to appear.

  • I am investigating…

    how the proteins’ activation in the thrombocytes changes under reduced oxygen levels compared to normal conditions. It is currently still unclear whether a reduced oxygen concentration activates the thrombocytes and thus leads to thrombosis, or whether it’s the other way around and the activated thrombocytes trigger an oxygen deficiency in the blood.

    To answer this question, the setting in which I conduct my experiments is important. To date, experiments with thrombocytes have mostly been conducted at an oxygen level of 21% - that of the air. In the blood vessels, however, the oxygen content is lower and can drop even further during activation. My work will help to better understand the effect of oxygen deficiency on thrombocytes under real-life conditions.

  • For my bachelor’s thesis, I am conducting research at ISAS because…

    I am interested in analytical chemistry in the context of health research. I was immediately fascinated by the idea of being able to do research on thrombocytes from human samples. I hope that my work can support the scientists at ISAS in identifying makers for an early thrombocyte reaction in patients – and thus ultimately reduce the risk of thrombosis.


Further articles

31st January 2023

ISAS Congratulates Sven Heiles on his Habilitation

With his presentation about analytical chemistry in paleontology at Justus Liebig University (JLU) Giessen, Heiles successfully completed his habilitation.

Prof. Dr. Sven Heiles.
27th January 2023

Guest Presentation: New Framework for Stem Cell Analysis

Dr Susanne Rafelski, deputy director of scientific programme at the Allen Institute for Cell Science is a guest at ISAS on 7 February.

Portrait Susanne Rafelski.
26th January 2023

ISAS Organises 54th DGMS Conference - Registration Now Open

The annual meeting of the German Society for Mass Spectrometry in Dortmund from May 14-17 will focus on mass spectrometric techniques and research.

Bild vom Dortmunder Hafen bei Nacht.
15th December 2022

Newborn Screening: Plasma-Based Ionisation for Faster Diagnosis?

When it comes to newborn screenings, every minute counts. The earlier doctors can diagnose hormonal or metabolic diseases, the better the infants' therapeutic prospects. In the interview, Dr Marcos Bouza Areces reports on his research.

Porträt Dr. Marcos Bouza Areces.
2nd December 2022

Skyline Course 2023 – Register Now

From 20 to 23 March 2023, beginners and advanced users from science and the industry will have the opportunity to train using the open source software.

Skyline Logo.
29th November 2022

Sven Heiles Receives Justus Liebig University Giessen Award

Congratulations to Prof Dr Sven Heiles, head of the junior research group Lipidomics at ISAS: For his outstanding scientific achievements, he received the award of the Justus Liebig University Giessen.

JLU-Präsident Prof. Dr. Joybrato Mukherjee überreicht Prof. Dr. Sven Heiles die Urkunde zum JLU-Preis beim akademischen Festakt in Gießen.
21st November 2022

What are you doing at ISAS, Konrad?

How does a mathematician from Berlin end up in one of the labs at ISAS when it comes to health research? And what does his stay have to do with science communication? Konrad Krug, a trainee at the Leibniz Association, has the answers.

Konrad Krug, Volontär bei der Leibniz-Gemeinschaft, besucht am ISAS eines der Labore.
28th October 2022

Guest at ISAS: Colloquium with Prof Dr Harald H.H.W. Schmidt

The redefinition of diseases and the organisation of medicine by means of Big Data - these aspects will be the subject of the lecture by systems medicine pioneer Prof. Dr. Harald H.H.W. Schmidt.

Portrait Prof. Dr. Harald H.H.W. Schmidt.
21st October 2022

Hydrogen Sulfide: Is This Foul Compound a Fountain of Youth?

What role does hydrogen sulfide play in ageing processes? How does the foul gas affect normal brain function? Dr habil. Miloš Filipović and his team at ISAS are investigating these questions.

Porträt Dr. habil. Miloš Filipović.