Research
Proteomics
Cell-cell interactions in wound healing
Despite being of heterogeneous lineage, gene expression has been found to vary significantly resulting in a variety of inconsistent expression levels. As a result, the genetic variances between individual keloid and non-keloid derived cells will be investigated. > more
Near-field Raman Spectroscopy
In many scientific areas, samples must be investigated with high lateral resolution. Good examples are cells, cell compounds (DNA, RNA, proteins), viruses as well as integrated circuits in semiconductor science. > more
Screening of novel heme-enzyme catalysts
Surface-enhanced Raman scattering (SERS) is a sensitive Raman technique which can provide information on molecular structure and specific molecular interactions. It uses a suitable roughened metal surfaces leading to a substantial enhancement over normal Raman scattering. > more
Improved quantification approaches for protein analysis
It is the aim of this project to develop new approaches for detection and quantification of proteins by use of spectroscopic methods. In the first step, naturally occuring heteroelements (S, P, metals) are used as indicator elements for detection and quantification of specific proteins by means of inductively plasma mass spectrometry (ICP-MS). > more
Imaging of bio-chemical information
It is the aim of this project to make different image processing techniques available for the analytical spectroscopic methods used in the institute and their enhancement. In general, for the examination of inhomogeneous samples or inhomogeneous surfaces an integral examination is insufficient. Desirable is a method which takes the spatial distribution of ... > more
Force Microscopy Imaging
The focus of interest in analytical sciences is shifting from homogeneous specimens to samples with complex composition. Examples are mixed polymers, chips, or biological samples. Frequently, chemical composition varies on the nanometre scale. Atomic force microscopy (AFM) allows measurements with such a spatial resolution. While the standard operation mode of an AFM yields just the topography of the sample with such a resolution, other modes can be used to even observe a chemical contrast with the same spatial resolution. > more