alte Seiten

Synthetic biomolecules are optimal tools to improve analytical methods of enrichment, identification and quantification of specific components in biological systems. Such tools are also highly valuable for studying protein-binding interactions, development of diagnostics, and in the long run, even therapeutics. In contrary to biological isolates, they offer defined chemical structures and can be prepared as homogenous samples, thus being easily modified to include synthetic handles for improved detection or purification. The focus of our research area is to generate tools by organic synthesis of complex molecules to study post-translational modifications with particular focus on glycosylation processes. We are interested in synthesis of glycopeptide analytical standards for enrichment, quantification and MS fragmentation behavioural studies, synthesis of mucin glycopeptides for host-microbe binding interaction investigations and generation of antibodies via synthetic vaccines as tools to study changes of glycosylation related to certain diseases.